Effect of Eurycoma longifolia Jack on Laevator Ani Muscle in Both Uncastrated and Testosterone-Stimulated Castrated Intact Male Rats

  • Ang, Hooi-Hoon (School of Pharmaceutical Science, University Scinece Malaysia) ;
  • Cheong, Hung-Seong (School of Pharmaceutical Science, University Scinece Malaysia)
  • Published : 2001.10.01

Abstract

It has been reported that Eurycoma longifolia Jack commonly known as Tongkat Ali has gained notoreity as a symbol of man's ego and strength by the Malaysian men because it increases male virility and sexual prowess during sexual activities. As such, the effects of 200, 400 and 800 mg/kg of butanol, methanol, water and chloroform fractions of E. longifolia Jack were studied on the laevator am muscle in both uncastrated and testosterone-stimulated castrated intact male rats after dosing them for 12 consecutive weeks. Results showed that 800 mg/kg of butanol, methanol, water and chloroform fractions of E. longifolia Jack significantly increased (p<0.05) the leavator am muscle to 58.56$\pm$1.22, 58.23 $\pm$0.31, 60.21 $\pm$0.86 and 62.35 $\pm$0.98 mg/100 g body weight, respectively, when compared with the control (untreated) in the uncastrated intact male rats and 49.23 $\pm$0.82, 52.23 $\pm$ 0.36, 50.21 $\pm$ 0.66 and 52.35 $\pm$ 0.58 mg/100 g body weight, respectivety, when compared to control (untreated) in the testosterone-stimulated castrated intact male rats. Hence the proandrogenic effect as shown by this study further supported the traditional use of this plant as an aphrodisiac.

Keywords

References

  1. Planta Med. v.61 In vitro antimalarial activity of quassinoids from Eurycoma longifolia against Malaysian chloroquine-resistant Plasmodium falciparum isolates Ang,H.H.;Chan,K.L.;Mak,J.W.
  2. J. Ethnopharmacol. v.49 Effect of 7-day daily replacement of culture medium containing Eurycoma longifolia Jack constituents on the Malaysian Plasmodium falciparum isolates Ang,H.H.;Chan,K.L.;Mak,J.W.
  3. Planta Med. v.52 Plants as sources of antimalarial drugs. Part 3. Eurycoma longifolia Jack Chan,K.L.;O'Neill,M.J.;Phillipson,J.D.;Warhurst,D.C.
  4. Phytochemistry v.28 A quassinoid glycoside from the roots of Eurycoma longifolia Chan,K.L.;Lee,S.P.;Sam,T.W.;Han,B.H.
  5. UNIMAS,Sarawak,Malaysia,Proceeding Antipyretic Activity of Quassinoids from Eurycoma longifolia Jack. Paper presented at the 11th Chemical Seminar on Natural Products Chen,K.L.;Lee,S.P.;Yuen,K.H.
  6. A Dictionary of Malayan Medicine Gimlett,J.D.;Thomson,J.W.(eds.)
  7. Chem. Pharm. Bull. v.40 Cytotoxic Quassinoids and Tirucallane-Type Triterpenes from the Woods of Eurycoma longifolia Itokawa,H.;Kishi,E.Morita,H.;Takeya,K.
  8. Chem. Pharm. Bull. v.41 Novel Quassinoids from Eurycoma longifolia Itokawa,H.;Oin,X.R.;Morita,H.;Takeya,K.;Iitaka,Y.
  9. J. Nat. Prod. v.54 Cytotoxic and antimalarial constituents of the roots of Eurycoma longifolia Kardono,L.B.S.;Angerhofer,C.K.;Tsauri,S.;Padmawinata,K.;Pezzuto,J.M,;Kinghorn,D.
  10. Chem. Lett. v.5 New Quassinoids from the roots of Eurycoma longifolia Morita,H.;Kishi,E.;Takeya,K.;Itokawa,H.;Iitaka,Y.
  11. Phytochemistry v.34 Squalene derivatives from Eurycoma longifolia Morita,H.;Kishi,E.;Takeya,K.;Itokawa,H.;Iitaka,Y.
  12. Statistics for Health Professionals Schefler,W.C.
  13. Eur. J. Med. Chem. v.26 New antiulcer quassinoids from Eurycoma longifolia Tada,H.;Yasuda,F.;Otani,K.;Doteuchi,M.;Ishihara,Y.;Shiro,M.
  14. Experimental endocrinology,A sourcebook of basic techniques Zarrow,M.H.;Yochim,J.M.;McCarthy,J.L.;Sanborn,R.C.