Biomolecules & Therapeutics
- Volume 9 Issue 1
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- Pages.33-39
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- 2001
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- 1976-9148(pISSN)
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- 2005-4483(eISSN)
Efficacy of Physostigmine and Procyclidine as Combinational Prophylactics of Organophosphate Poisoning
Physostigmine과 procyclidine으로 구성된 복합예방제의 유기인제 해독효능
- Hur, Gyeung-Haeng (CBR Department (GSDC-2-4), Agency for Defense Development) ;
- Choen, Ki-Cheol (CBR Department (GSDC-2-4), Agency for Defense Development) ;
- Phi, Taek-San (CBR Department (GSDC-2-4), Agency for Defense Development) ;
- Kim, Jae-Cheon (CBR Department (GSDC-2-4), Agency for Defense Development) ;
- Hong, Dea-Sik (CBR Department (GSDC-2-4), Agency for Defense Development) ;
- Park, Hoon (CBR Department (GSDC-2-4), Agency for Defense Development) ;
- Jung, Chang-Hee (CBR Department (GSDC-2-4), Agency for Defense Development) ;
- Lee, Yong-Han (CBR Department (GSDC-2-4), Agency for Defense Development) ;
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Kim, Yun-Bae
(CBR Department (GSDC-2-4), Agency for Defense Development)
- 허경행 (국방과학연구소 제1체계개발본부 2부) ;
- 천기철 (국방과학연구소 제1체계개발본부 2부) ;
- 피택산 (국방과학연구소 제1체계개발본부 2부) ;
- 김지천 (국방과학연구소 제1체계개발본부 2부) ;
- 홍대식 (국방과학연구소 제1체계개발본부 2부) ;
- 박훈 (국방과학연구소 제1체계개발본부 2부) ;
- 정창희 (국방과학연구소 제1체계개발본부 2부) ;
- 이용한 (국방과학연구소 제1체계개발본부 2부) ;
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김윤배
(국방과학연구소 제1체계개발본부 2부)
- Published : 2001.03.01
Abstract
Antidotal efficacy of combinational prophylactics composed of physostigmine plus procyclidine, alone or in combination with antidotes such as atropine plus 2-pralidoxime or atropine plus HI-6, was evaluated in rats. Physostigmine (0.1 mg/kg) plus procyclidine (3 mg/kg), pretreated subcutaneously 30 min prior to subcutaneous exposure to organophosphates of militarily importance, exerted protection ratios of 7.2, 6.5, 4.0, 2.9 and 8.0 fold for tabun, saris, soman, cyclosarin and V-agent, respectively. In comparison, low effects (1.7 fold for soman and 1.3 fold for cyclosarin) were achieved with the traditional antidotes atropine (17.4 mg/kg) plus 2-pralidoxime (30 mg/kg) administered intramuscularly immediately after organophosphate, in contrast to high effects (5.5 fold for soman and 160.0 fold for cyclosarin) with atropine (17.4 mg/kg) plus HI-6 (125 mg/kg), although the protection ratio markedly decreased when treatment of antidotes was delayed. Note- worthy, the combinational prophylactics markedly potentiated the effects of antidotes to higher than 5.0 fold in all cases. In addition, the combinational prophylactics fully prevented the seizures and excitotoxic brain injuries induced by a high dose (100 mg/kg, 1.3 LD