Journal of Veterinary Clinics (한국임상수의학회지)

The Korean Society of Veterinary Clinics (한국임상수의학회)
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Antifungal Susceptibility Testing for the Dermatophytes Isolated from Dogs and Cats

개와 고양이에서 분리한 피부사상균에 대한 항진균제의 감수성시험

  • Shin, Jae-Eun (Department of Veterinary Medicine, Kangwon National University) ;
  • Sung, Choong-Hyun (Department of Veterinary Medicine, Kangwon National University) ;
  • Kim, Doo (Department of Veterinary Medicine, Kangwon National University)
  • 신재은 (강원대학교 동물자원과학대학 수의학과) ;
  • 성충현 (강원대학교 동물자원과학대학 수의학과) ;
  • 김두 (강원대학교 동물자원과학대학 수의학과)
  • Published : 2001.03.01
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Abstract

The aim of this study was to determine optimal therapeutic dose of antifungal agents for dermatophytes. Forty nine dermatophytes were isolated form dogs and cats showing skin lesions and were tested for their in vitro susceptibility to nystatin, griseofulvin, terbinafine, ketoconazole and fluconazole by broth microdilution test. Terbinafine showed the lowest MIC value among the antifungal agents tested, and MIC values ranged from 0.002 to 0.016 $\mu\textrm{g}$/ml. Fluconazole showed the highest MIC values among the antifungal agents tested, and MIC values ranged from 32 to 512 $\mu\textrm{g}$/ml. MIC values of nystatin, griseofulvin and ketoconazole ranged from 1.12 to 4.48 $\mu\textrm{g}$/ml, 0.5 to 4.0 $\mu\textrm{g}$/ml, and 1.6 to 12.8 $\mu\textrm{g}$/ml, resistant to griseofulvin, and that antifungal susceptibility test was needed to determine optimal therapeutic dose of antifungal agents for each dermatophyte.

Keywords

References

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