Antibacterial Compound against Pasturella multiocida and Actinobacillus pleuropneumoniae Causing Porcine Pneumonia

  • Lyoo, Young-Soo (Department of Veterinary Medicine, Konkuk University) ;
  • Park, Dong-Ki (Department of Applied Biology & Chemistry, Konkuk University) ;
  • Lee, Sang-Mok (Department of Veterinary Medicine, Konkuk University) ;
  • Choi, Yi-Don (Department of Veterinary Medicine, Konkuk University) ;
  • Jung, Ji-Hyun (Department of Applied Biology & Chemistry, Konkuk University) ;
  • Jun, Tae-Il (Department of Applied Biology & Chemistry, Konkuk University) ;
  • Ahn, Hong-Suk (Department of Applied Biology & Chemistry, Konkuk University) ;
  • Lee, Chul-Hoon (Department of Medical Genetics & Institute of Biomedical Science, College of Medicine, Hanyang University) ;
  • Lim, Yoong-Ho (Department of Applied Biology & Chemistry, Konkuk University)
  • Published : 2001.04.01

Abstract

Porcine pneumonia is caused by Pasturella multiocida and Actinobacillus pleuropneumoniae. To identify a potent drug for antipneumonia therapy, several herbal compounds showing antibacterial effects were screened, and it was found that a methanol extract of Coptidis rhizoma root stem exhibited activity against both pneumonia-causing bacteria. Using an activity-guided fragmentation procedure, an isoquinoline alkaloid was isolated which would be responsible for the antibacterial activities against P. multocida and A. pleuropneumoniae.

Keywords

References

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