척담탕가미방이 혈압, 뇌혈류량 및 평활근에 미치는 효능에 관한 연구

Study on the Effects of Chukdamtanggamibang on blood pressure, regional cerebral blood flow(rCBF) and smooth muscle

  • 이건목 (원광대학교 한의과대학 침구학교실) ;
  • 천미나 (원광대학교 한의과대학 침구학교실) ;
  • 서은미 (원광대학교 한의과대학) ;
  • 한종현 (원광대학교 한의과대학 약리학교실) ;
  • 이호섭 (원광대학교 한의과대학 약리학교실) ;
  • 김경식 (원광대학교 한의과대학 약리학교실) ;
  • 황우준 (원광대학교 한의과대학 약리학교실) ;
  • 이병철 (원광대학교 한의과대학 약리학교실)
  • 발행 : 2001.02.01

초록

This study was aimed to investigate the effect Chukdamtanggamibang on the vascular systems including changes in blood pressure and regional cerebral blood flow(rCBF) of male Sprague-Dawely rats, contractile force of guinea pig`s tracheal smooth muscle and abdominal aorta and femoral artery in rabbits. Blood pressure was not affected by Chukdamtanggamibang in rats. rCBF was significantly increased by Chukdamtanggamibang in a dose-dependent manner. Contractile force of isolated guinea pig`s tracheal smooth muscle evoked by His ({TEX}$ED_{50}${/TEX}) were inhibited significantly by Chukdamtanggamibang. Propranolol, indomethacin and methylene blue did not significantly alter the inhibitory effect of Chukdamtanggamibang. Contractile force of isolated rabbit`s abdominal aorta and femoral artery evoked by NE ({TEX}$ED_{50}${/TEX}) were inhibited significantly by Chukdamtanggamibang. ODQ and L-NNA significantly attenuated the inhibitory effects of Chukdamtanggamibang in abdominal aorta, whereas propranolol did not significantly alter the inhibitory effect of Chukdamtanggamibang. These results indicate that Chukdamtanggamibang can relax hitamine-induced contraction of guinea pig`s tracheal smooth muscle and that this inhibition involves, in part, the relation to the soluble guanylyl cyclase synthesis and nitric oxide (NO) synthesis.

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