Journal of Acupuncture Research

Korean Acupuncture & Moxibustion Medicine Society (대한침구의학회)
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The Effect of Plantaginis Semen Aquacupuncture on CCl4 Induced Hepatoxicity in Rats

CCl4로 유발(誘發)한 백서(白鼠) 간손상(肝損傷)에 미치는 차전자약침(車前子藥鍼)의 영향(影響)

  • Kwon, Seon-Ho (Department of AM-Meridian & Pointology, College of Oriental Medicine, Dong-Eui University) ;
  • Song, Choon-Ho (Department of AM-Meridian & Pointology, College of Oriental Medicine, Dong-Eui University)
  • 권선호 (동의대학교 한의과대학 경혈학교실) ;
  • 송춘호 (동의대학교 한의과대학 경혈학교실)
  • Received : 2001.07.05
  • Accepted : 2001.07.21
  • Published : 2001.08.20
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Abstract

Objective : This study was undertaken to determine if Plantaginis Semen Aquacupuncture(PSA) has a protective effect against $CCl_4$ induced Hepatoxicity in Rats. Methods : The experimental group were divided into Normal group(untreated group), Control group, PSA group. Rats were administered orally $CCl_4$(0.1 ml/kg) for 4 days. In experiments for PSA effect, rats received 0.1 ml of PSA extraction in both sides of corresponding $G{\bar{a}}nsh{\bar{u}}$(BL18) of human body for 3 days after treated $CCl_4$. Variation of weight and biochemical assays(GOT, GPT, LDH, ALP, total cholesterol, triglyceride, albumin) were performed. Results : In Control group, $CCl_4$ increased serum GOT, GPT, LDH, ALP and albumin and decreased weight, total cholesterol and triglyceride. PSA significantly decreased serum GOT, GPT, LDH and increased total cholesterol as compared with Control group. Conclusion : These results indicate that PSA could be used in prevention and treatment of hepatoxicity. However, precise mechanisms of PSA protection remain to be determined.

Keywords

References

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