Childhood Kidney Diseases

Korean Society of Pediatric Nephrology (대한소아신장학회)
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A Case of Membranoproliferative Glomerulonephritis Type II (Dense Deposit Disease, DDD)

막성증식성 사구체신염 제 II형 (Dense Deposit Disease, DDD) 1례

  • Kwon Hae Sik (Departments of Pediatrics, The Institute of Kidney Disease, Yonsei University College of Medicine) ;
  • Oh Seung-Jin (Departments of Pediatrics, The Institute of Kidney Disease, Yonsei University College of Medicine) ;
  • Lee Young-Mock (Departments of Pediatrics, The Institute of Kidney Disease, Yonsei University College of Medicine) ;
  • Kim Ji Hong (Departments of Pediatrics, The Institute of Kidney Disease, Yonsei University College of Medicine) ;
  • Kim Pyung-Kil (Departments of Pediatrics, The Institute of Kidney Disease, Yonsei University College of Medicine) ;
  • Kang Hae Youn (Departments of Pediatrics, The Institute of Kidney Disease, Yonsei University College of Medicine) ;
  • Jeong Hyeon Joo (Departments of Pathology, The Institute of Kidney Disease, Yonsei University College of Medicine) ;
  • Choi In Joon (Departments of Pathology, The Institute of Kidney Disease, Yonsei University College of Medicine)
  • 권해식 (연세대학교 의과대학 소아과학교실) ;
  • 오승진 (연세대학교 의과대학 소아과학교실) ;
  • 이영목 (연세대학교 의과대학 소아과학교실) ;
  • 김지홍 (연세대학교 의과대학 소아과학교실) ;
  • 김병길 (연세대학교 의과대학 소아과학교실) ;
  • 강혜윤 (연세대학교 의과대학 병리학교실) ;
  • 정현주 (연세대학교 의과대학 병리학교실) ;
  • 최인준 (연세대학교 의과대학 병리학교실)
  • Published : 2001.10.01
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Abstract

Type II membranoproliferative glomerulonephritis (Dense deposit disease) is an acquired primary glomerular disease characterized by electron microscopic evidence of a continuous dense membrane deposition replacing the lamina densa. It is a subtype of idiopathic membra- noproliferative glomerulonephritis, and was described as a separate entity by Berger and Galle in 1963. It frequently occurs in older chilren and young adults and the clinical course is variable, but is generally progressive. The presenting feature is nephrotic syndrome in many patients, and proteinuria and hematuria are also seen frequently. The purpose of this paper is to present a case of DDD (Dense deposit disease) from a 10 year old boy who was diagnosed as a acute poststreptococcal glomurulonephritis with protenuria, hematuria, and facial edema by renal biopsy 4 years ago. (J, Korean Soc Pediatr Nephrol 2001 ; 5 : 188-95)

제2형 막증식성 사구체 신염은 전자현미경 검사 상 기저막 내에 리본과 같은 형태의 전자고밀도물질이 참착되어 지속적인 보체의 감소와 혈뇨, 단백뇨등을 나타내는 원발성 사구체 질환이다. 저자들은 내원 4년 전에 신장조직검사상 연쇄상구균 감염 후 급성사구체 신염을 진단 받은 후 4년 이상 지속되는 혈뇨와 보체의 감소로 재차 시행한 신장조직검사상 확진된 제 2형 막증식성 사구체신염 1례를 경험하였기에 국내외 문헌 고찰과 함께 보고하는 바이다.

Keywords