Journal of Pharmaceutical Investigation
- Volume 31 Issue 2
- /
- Pages.113-117
- /
- 2001
- /
- 2093-5552(pISSN)
- /
- 2093-6214(eISSN)
Development of Liposomal Formulation of A Camptothecin Derivative
캄프토테신 유도체의 리포좀 제형 개발
- Shim, Jin-Young (College of Pharmacy, Sookmyung Women's University) ;
- Kim, Jin-Seok (College of Pharmacy, Sookmyung Women's University)
- Published : 2001.06.20
Abstract
CKD602, a camptothecin derivative, is a synthetic and water-soluble anticancer agent possessing of topoisomerase I inhibiting activity. DPPC and DSPE-PEG liposomal formulations entrapped with CKD602 were developed. DSPE-PEG liposome, or PEGylated liposome, encapsulating CKD602 composed of dipalmitoylphosphatidylcholine (DPPC), cholesterol and distearoyl-N-monoethoxy poly (ethyleneglycol) succinylphosphatidylethanolamine