Korean Journal of Pharmacognosy (생약학회지)
- Volume 32 Issue 2 Serial No. 125
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- Pages.103-107
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- 2001
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- 0253-3073(pISSN)
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- 2288-9299(eISSN)
Effects of the Water Extract from the Stem Bark of Acanthopanax senticosus on Hyperlipidemia in Rats
가시오갈피 줄기의 물 추출물이 지질대사에 미치는 영향
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Lee, Yeon-Sil
(Natural Products Research Institute, Seoul National University) ;
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Jung, Sang-Hoon
(Natural Products Research Institute, Seoul National University) ;
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Lim, Soon-Sung
(Natural Products Research Institute, Seoul National University) ;
- Ji, Jun (Natural Products Research Institute, Seoul National University) ;
- Lee, Sang-Hyun (Natural Products Research Institute, Seoul National University) ;
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Shin, Kuk-Hyun
(Natural Products Research Institute, Seoul National University)
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이연실
(서울대학교 천연물과학연구소) ;
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정상훈
(서울대학교 천연물과학연구소) ;
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임순성
(서울대학교 천연물과학연구소) ;
- 지준 (서울대학교 천연물과학연구소) ;
- 이상현 (서울대학교 천연물과학연구소) ;
-
신국현
(서울대학교 천연물과학연구소)
- Published : 2001.06.30
Abstract
The effects of the water extract from the stem bark of Acanthopanax senticosus were evaluated on hyperlipidemic rats induced by lipid rich diet or poloxamer-407. The water extracts, when administered orally for 3 consecutive days in hyperlipidemic rats induced by poloxamer-407 (1 ml of 30%), was found to cause a significant decrease in plasma cholesterol and triglyceride concentrations. The water extracts, when treated orally for 5 consecutive days also showed a significant inhibition of serum total cholesterol and triglyceride level in rats treated with lipid rich diet (15% cholesterol, 1% sodium cholate and 84% com oil). HDL-cholesterol, however, was increased significantly.
Keywords
- Acanthopanax senticosus;
- hypolipidemic action;
- cholesterol;
- triglyceride;
- poloxamer-407;
- lipid-rich diet