Journal of the Korean Wood Science and Technology
- Volume 29 Issue 4
- /
- Pages.89-96
- /
- 2001
- /
- 1017-0715(pISSN)
- /
- 2233-7180(eISSN)
Studies on Biological Activity of Wood Extractives(VII) - Antifungal activity of Isoflavonoids from Sophora japonica -
수목추출물의 생리활성에 관한 연구(VII) - 회화나무 Isoflavonoid의 항균활성 -
- Park, Young-Ki (Dept. of Forest Resources, Dongguk University) ;
- Lee, Hak-Ju (Div. Wood Chemistry and Microbiology, KFRI) ;
- Lee, Sung-Suk (Div. Wood Chemistry and Microbiology, KFRI) ;
- Choi, Don-Ha (Div. Wood Chemistry and Microbiology, KFRI) ;
- Yeo, Woon-Hong (Div. Wood Chemistry and Microbiology, KFRI) ;
-
Oh, Jung-Soo
(Dept. of Forest Resources, Dongguk University)
- 박영기 (동국대학교 산림자원학과) ;
- 이학주 (임업연구원 화학미생물과) ;
- 이성숙 (임업연구원 화학미생물과) ;
- 최돈하 (임업연구원 화학미생물과) ;
- 여운홍 (임업연구원 화학미생물과) ;
-
오정수
(동국대학교 산림자원학과)
- Received : 2001.10.08
- Accepted : 2001.11.06
- Published : 2001.12.30
Abstract
Three isoflavones and one isoflavanone were isolated from the wood of Sophora japonica (Leguminosae) which has been selected due to its high antifungal activity among the tested species, Four compounds were identified as 5,7-dihydroxy-4',6-dimethoxyisoflavone (irisolidone), 5,7-dihydroxy-4'-methoxyisoflavone (biochanin A), 7-hydroxy-4'-methoxyisoflavone (formononetin) and 7-hydroxy-4'-methoxy-isoflavanone by Mass and NMR spectroscopic analysis. The antifungal activity of the isoflavonoids was tested by medium dilution method and showed low antifungal activity indicating that the other compounds may contribute to high activity of the wood extractives of S. japonica.
항균활성이 우수한 회화나무 목부로부터 4종의 isoflavonoid 화합물을 단리하였으며, 기기분석 결과 3종의 isoflavone인 5,7-dihydroxy-4',6-dimethoxyisoflavone(irisolidone)을 비롯하여, 5,7-dihydroxy-4'-methoxyisoflavone(Biochanin A), 7-hydroxy-4'-methoxyisoflavone(formononetin) 그리고 1종의 isoflavanone인 7-hydroxy-4'-methoxyisoflavanone으로 각각 동정하였다. 이들 단리 물질의 항균활성을 배지점적법으로 조사한 결과 4종의 isoflavonoid 공히 낮은 항균활성을 나타내어, 회화나무 목부의 높은 항균활성은 본 실험에서 단리한 물질 이외의 물질이 관여하는 것으로 추정되며 금후 관련물질의 탐색이 필요할 것으로 사료되었다.