생물정신의학 (Korean Journal of Biological Psychiatry)
- 제7권2호
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- Pages.164-173
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- 2000
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- 1225-8709(pISSN)
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- 2005-7571(eISSN)
알코올 장기투여시 비타민 또는 Piracetam의 병합투여가 백서 해마와 소뇌 신경세포의 미세형태학적 구조에 미치는 영향
Effects of Long-Term Alcohol Treatment Combined with Vitamins or Piracetam on the Ultrastructure of Rat Hippocampal and Cerebellar Neurons
- 손창호 (인제대학교 의과대학 서울백병원 신경정신과학교실) ;
-
이상익
(충북대학교 의과대학 신경정신과학교실) ;
- 곽정식 (경북대학교 의과대학 해부병리학교실) ;
- 정인원 (충북대학교 의과대학 신경정신과학교실)
- Sohn, Chang-Ho (Department of Neuropsychiatry, Seoul Paik Hospital, Inje Medical College) ;
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Lee, Sang-Ik
(Department of Neuropsychiatry, School of Medicine, Chungbuk National University) ;
- Kwak, Jeong-Sik (Department of Pathology, School of Medicine, Kyungbuk National University) ;
- Jeong, In-Won (Department of Neuropsychiatry, School of Medicine, Chungbuk National University)
- 발행 : 2000.12.31
초록
This study was carried out to investigate the direct neurotoxicity of alcohol on CNS and the effects of piracetam or vitamins on ultrastructural changes of the rat cerebellar and hippocampal neurons during long-term alcohol treatment. To evaluate the results, quantitative analysis were done for light and electronic microscopic findings. On the light microscopy, red degeneration of pyramidal cells and Purkinje cells was found more apparently in the alcohol only treated group than in the control group. On the electron microscopy, increased lipofuscin pigments were found in cerebellum and hippocampus. In quantitative analysis, vitamins significantly reduced red degeneration in both hippocampus and cerebellum. However, piracetam significantly reduced red degeneration in cerebellum but not in hippocampus. Lipofuscin pigments in Purkinje cells and pyramidal cells were significantly reduced in the alcohol with piracetam treated group than the alcohol only treated group. However, vitamins had no significant reducing effect of lipofuscin pigments in Purkinje cells and pyramidal cells. According to the results, it is concluded that vitamins deficiency might cause red degeneration of pyramidal cell after long-term alcohol treatment, but increment of lipofuscin pigments in pyramidal and Purkinje cell may be caused by alcohol itself or its metabolite rather than vitamins deficiency. Piracetam seems to improve cognitive function impairment caused by alcohol consumption.
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