The effect of Galwhahaejungtang and exercise on variation of lipid, BUN and Creatinine in rat with alcohol administration

갈화해성탕(葛花解醒湯) 투여 및 운동 부하가 알코올 섭취 후 흰쥐의 혈청 지질, BUN, Creatinine 함량에 미치는 영향

Galwhahaejungtang has been used to alcoholic disease. Object of This study is examining the effect of Galwhahaejungtang and exercise on variation of total cholesterol, HDL-cholesterol, triglyceride, free fatty acid, BUN, Creatinine in rat with alcohol administration. METHODS AND MATERIALS Fifty four rats were divided into four groups. 1. The group of rat with alcohol administration and no treatment 2. The group of rat with alcohol and Galwhahaejungtang administration 3. The group of rat with alcohol administation and exercise 4. The group of rat with alcohol, Galwhahaejungtang administration and exercise Serum of rat were obtained after 2 weeks and 4 weeks. RESULTS 1. The level of total cholesterol was decreased in the group of rat with Galwhahaejungtang administration and exercise after 2 weeks. After 4 weeks, the level of total cholesterol was significantly decreased in the group of rat with Galwhahaejungtang administration and exercise. 2. The level of HDL-cholesterol was significantly increased in the group of rat with exercise after 2 weeks. After 4 weeks, the level of HDL-cholesterol was significantly increased in the group of rat with no treatment and with Galwhahaejungtang administration. 3. The level of try glyceride was significantly decreased in the group of rat with exercise after 2 weeks. After 4 weeks, the level of tryglyceride was significantly decreased in the group of rat with Galwhahaejungtang administration. 4. The level of free fatty acid was significantly decreased in the group of rat with Galwhahaejungtang administration after 2 weeks. After 4 weeks, the level of free fatty acid was significantly decreased in the group of rat with Galwhahaejungtang administration and with Galwhahaejungtang administration and exercise. 5. The level of BUN was significantly decreased in the group of rat with Galwhahaejungtang administration and exercise after 2 weeks. After 4 weeks, the level of BUN was significantly decreased in the group of rat with exercise. 6. The level of creatinine was significantly decreased in the group of rat with Galwhahaejungtang administration and exercise. After 4 weeks, the level of creatinine was significantly decreased in the group of rat with exercise and with Galwhahaejungtang administration and exercise. CONCLUSION Based on these results, it is considered that Galwhahaejungtang administration and exercise has an accelerating effect on alcohol metabolism.

갈화해성탕(葛花解醒湯)은 역대로 주상병(酒傷病)에 쓰여진 대표적인 처방이다. 이 연구에서는 알콜 투여 후 자연회복군, 알콜 투여 후 갈화해성탕(葛花解醒湯) 투여군, 알콜 투여 후 운동 적용군, 알콜 투여 후 갈화해성탕(葛花解醒湯) 투여 운동 병행군으로 나누어 각각의 혈청 지질과 BUN, Creatinine의 함량 변화를 알아 보았다. 1. Total cholesterol 함량은 2주 후에는 갈화해성탕(葛花解醒湯) 투여 및 운동 병행군에서 감소하였고, 4주 후에는 갈화해성탕(葛花解醒湯) 투여 및 운동 병행군에서 유의성 있게 감소하였다. 2. HDL-cholesterol 함량은 2주 후에는 운동 적용군에서 유의성 있게 증가하였고, 4주 후에는 자연회복군, 갈화해성탕(葛花解醒湯) 투여군에서 유의성 있게 증가하였다. 3. Triglyceride 함량은 2주 후에는 운동 적용군에서 유의성 있게 감소하였고, 4주 후에는 갈화해성탕(葛花解醒湯) 투여군에서 유의성 있게 감소하였다. 4. Free fatty acid 함량은 2주 후에는 갈화해성탕(葛花解醒湯) 투여군에서 유의성 있게 감소하였고, 4주 후에는 갈화해성탕(葛花解醒湯) 투여군, 갈화해성탕(葛花解醒湯) 투여 및 운동 병행군에서 유의성 있게 감소하였다. 5. BUN 함량은 2주 후에는 갈화해성탕(葛花解醒湯) 투여 및 운동 병행군에서 유의성 있게 감소하였고, 4주 후에는 운동 적용군에서 유의성 있게 감소하였다. 6. Creatinine 함량은 2주 후에는 갈화해성탕(葛花解醒湯) 투여 및 운동 병행군에서 유의성 있게 감소하였고, 4주후에는 운동 적용군, 갈화해성탕(葛花解醒湯) 투여 및 운동 병행군에서 유의성 있게 감소하였다. 이상의 결과로 갈화해성탕(葛花解醒湯) 투여 및 운동부하는 알콜 대사량 증가의 효과가 있을 것으로 생각된다.