Journal of Periodontal and Implant Science
- 제30권4호
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- Pages.747-757
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- 2000
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- 2093-2278(pISSN)
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- 2093-2286(eISSN)
Cyclosporin A가 in vitro에서 조골세포에 미치는 영향
The Effect of Cyclosporin A on Osteoblast in vitro
- 김재우 (연세대학교 치과대학 치주과학교실, 치주조직재생연구소) ;
- 이현정 (연세대학교 치과대학 구강생물학교실) ;
- 강정화 (연세대학교 치과대학 구강생물학교실) ;
- 옥승호 (연세대학교 치과대학 구강생물학교실) ;
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최봉규
(연세대학교 치과대학 구강생물학교실) ;
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유윤정
(연세대학교 치과대학 구강생물학교실) ;
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조규성
(연세대학교 치과대학 치주과학교실, 치주조직재생연구소) ;
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최성호
(연세대학교 치과대학 치주과학교실, 치주조직재생연구소)
- Kim, Jae-Woo (Department of Periodontology, Research Institute for Periodontal Regeneration) ;
- Lee, Hyun-Jung (Department of Oral Biology, College of Dentistry, Yonsei University) ;
- Kang, Jung-Hwa (Department of Oral Biology, College of Dentistry, Yonsei University) ;
- Ohk, Seung-Ho (Department of Oral Biology, College of Dentistry, Yonsei University) ;
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Choi, Bong-Kyu
(Department of Oral Biology, College of Dentistry, Yonsei University) ;
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Yoo, Yun-Jung
(Department of Oral Biology, College of Dentistry, Yonsei University) ;
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Cho, Kyoo-Sung
(Department of Periodontology, Research Institute for Periodontal Regeneration) ;
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Choi, Seong-Ho
(Department of Periodontology, Research Institute for Periodontal Regeneration)
- 발행 : 2000.12.31
초록
Cyclosporin A(CsA) is an immunosuppressive agent widely used for preventing graft rejecting response in organ transplantation. The basic properties of CsA to osteoblast has not been well known yet. A better understanding of the mechanisms of CsA function on bone could provide valuable information regarding basic properties of bone remodeling, pharmacotherapeutic intervention in metabolic bone disease, and the consequences of immunosuppression in bone physiology. The purpose of this study was to investigate the effect of CsA on osteoblast by evaluating parameters of proliferation, collagen synthetic activity, alkaline phosphatase activity, and ALP mRNA expression in mouse calvarial cell. 1. CsA (
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