Analytical Science and Technology (분석과학)

The Korean Society of Analytical Sciences (한국분석과학회)
권호 표지

Analytical Determination of Alkylphenols, Chlorophenols and Bisphenol A in Biota Samples using Gas Chromatography/Mass Spectrometry

기체 크로마토그래피/질량분석기를 이용한 생물시료 중 알킬 페놀류, 클로로페놀류 및 비스페놀 A의 분석법

  • Hong, Jongki (Mass Spectrometry Team, Korea Basic Science Institute) ;
  • Kim, Hyup (Mass Spectrometry Team, Korea Basic Science Institute) ;
  • Baek, In-Girl (Mass Spectrometry Team, Korea Basic Science Institute) ;
  • Kim, Do-Gyun (Mass Spectrometry Team, Korea Basic Science Institute) ;
  • Seo, Jung-Joo (Mass Spectrometry Team, Korea Basic Science Institute) ;
  • Seo, Jong-Bok (Mass Spectrometry Team, Korea Basic Science Institute) ;
  • Chung, Bong-Chul (Korea Institute of Science and Technology) ;
  • Pyo, Hee-Soo (Korea Institute of Science and Technology) ;
  • Kim, Kyung-Rae (Department of Pharmacy, Sungkyunkwan University) ;
  • Kim, Yong-Hwa (Korea Research Institute of Chemical Technology)
  • 홍종기 (기초과학지원연구소, 질량분석팀, 정밀구조분석팀) ;
  • 김협 (기초과학지원연구소, 질량분석팀, 정밀구조분석팀) ;
  • 백인걸 (기초과학지원연구소, 질량분석팀, 정밀구조분석팀) ;
  • 김도균 (기초과학지원연구소, 질량분석팀, 정밀구조분석팀) ;
  • 서정주 (기초과학지원연구소, 질량분석팀, 정밀구조분석팀) ;
  • 서종복 (기초과학지원연구소, 질량분석팀, 정밀구조분석팀) ;
  • 정봉철 (한국과학기술연구원, 생체대사연구센터) ;
  • 표희수 (한국과학기술연구원, 생체대사연구센터) ;
  • 김경례 (성균관대학교, 약학대학) ;
  • 김용화 (한국화학연구소, 안전성센터)
  • Received : 2000.05.15
  • Published : 2000.08.25
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Abstract

The simultaneous analysis of alkylphenols, chlorophenols and bisphenol A in biota samples was performed by gas chromatography-mass spectrometry-selected ion monitoring mode. The phenols were extracted from sample with organic solvent and Forisil and Silica columns for clean-up procedure were compared. Recovery studies were performed at 1-ppm level of phenols added to each biota sample. Their recoveries ranged between 83 and 116% with coefficient of variations of 2.4-11.9%. To improve the detection limits of phenols, trimethylsilyl (TMS) derivatization was applied. The gas chromatographic properties of free phenols and TMS derivatized phenols were also investigated.

생물시료 중 존재하는 알킬페놀류, 클로로페놀류 및 비스페놀 A의 동시분석을 기체크로마토그래피-질량분석기-선택이온검색법에 의해 수행하였다. 시료 중 페놀류는 유기용매로 추출하고 정제과정은 Florisil과 silica 컬럼을 비교분석하였다. 회수율 실험은 각 생물시료에 1-ppm 정도를 첨가하여 수행하였다. 이들의 회수율은 83-116% 정도로 나타났고, 표준편차는 약 2.4-11.9%로 나타났다. 페놀류의 검출한계를 증진시키기 위하여, trimeaylsilyl(TMS) 유도체 방법을 도입하였다. 유도체화 시키지 않은 페놀과 TMS 유도체화된 페놀류의 기체크로마토그래피 성질을 연구하였다.

Keywords

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