The Korean Journal of Nuclear Medicine (대한핵의학회지)
- Volume 34 Issue 6
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- Pages.478-486
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- 2000
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- 1225-6714(pISSN)
Use of Mammary Lymphoscintigraphy and Intraoperative Radioguided Gamma Probe in Sentinel Lymph Node Biopsy of Breast Cancer
유방암 환자의 전초림프절 생검에서 유방림프신티그라피와 수술 중 감마프로우브의 유용성
- Kim, Soon (Department of Nuclear Medicine, Keimyung University, School of Medicine) ;
- Zeon, Seok-Kil (Department of Nuclear Medicine, Keimyung University, School of Medicine) ;
- Kim, Yu-Sa (Department of General Surgery, Keimyung University, School of Medicine)
- Published : 2000.12.30
Abstract
Purpose: The sentinel lymph node is defined as the first draining node from a primary tumor and reflects the histologic feature of the remainder of the lymphatic basin status. The aim of this study was to evaluate the usefulness of lymphoscintigraphy and intraoperative radioguided gamma probe for identification and removal of sentinel lymph node in breast cancer. Materials and Methods: Lymphoscintigraphy was performed preoperatively in 15 patients with biopsy proven primary breast cancer. Tc-99m antimony sulfide colloid was injected intradermally at four points around the tumor. Imaging acquisition included dynamic imaging, followed by early and late static images at 2 hours. The sentinel lymph node criteria on lymphoscintigraphy is the first node of the highest uptake in early and late static images. We tagged the node emitting the highest activity both in vivo and ex vivo. Histologic study for sentinel and axillary lymph node investigation was done by Hematoxylin-Eosin staining. Results: On lymphoscintigraphy, three of 15 patients had clear lymphatic vessels in dynamic images, and 11 of 15 patients showed sentinel lymph node in early static image and three in late static 2 hours image. Mean detection time of sentinel lymph node on lymphoscintigraphy was
목적: 조직 검사에서 유방암으로 확진된 환자 15명 (평균 연령 50.4세)을 대상으로 수술 전에 시행한 유방림프신티그라피(lymphoscintigraphy)와 수술 중 감마프로우브를 이용하여, 림프관 유입형태 및 전초림프절(sentinel lymph node)을 찾아, 전초 및 액와림프절을 각각 절제, 생검하여, 전초 림프절의 림프신티그라피 발현율, 전초림프절 전이와 액와림프절 전이의 상관 관계 등을 보고자 하였다. 대상 및 방법: 환자의 임상병기는 병기 I-II 이었고, 4례에서 액와림프절이 촉지되었다. 침습성 관암 13명, 수질암 및 포도당 풍부암이 각각 1명씩이었다. 유방림프신티그라피는 다음과 같이 시행하였다. 방사성의약품 Tc-99m antimony sulfide colloid
Keywords
- Tc-99m antimony sulfide colloid;
- Lymphoscintigraphy;
- Intraoperative radioguided gamma probe;
- Sentinel lymph node;
- Breast cancer