Journal of Nutrition and Health

The Korean Nutrition Society (한국영양학회)
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The Inhibitory Effects of Propolis on In Vitro Proliferation of Human Cancer Cell Lines

Propolis의 인체 암세포 증식억제 효과에 대한 In Vitro 연구

  • 이현수 (고려대학교 의과대학 생화학교실) ;
  • 이지영 (고려대학교 한국영양문제연구소) ;
  • 김동청 (고려대학교 한국영양문제연구소) ;
  • 인만진 (청운대학교 식품영양학과) ;
  • 황우익 (고려대학교 의과대학 생화학교실)
  • Published : 2000.01.01
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Abstract

This study was undertaken to investigate the inhibitory effects of propolis on the in vitro proliferation of human colon(HT-29) and hepatoma(HepG2) cancer cell lines. The growth of the HT-29 and HepG2 cells was respectively inhibited by the administration of propolis in a concentration response-dependent manner. The distributions of HT-29 and HepG2 cells cultured in the medium containing propolis were shifted to the smaller sizes, and then HT-29 and HepG2 cells were shrunken under microscopic observations. The progression of cell cycle from G1 to S phase was significantly inhibited by propolis in the HT-29 and HepG2 cell lines, respectively. Those observations suggest that propolis has anticancer effect against some of cancer cell lines in vitro. (Korean J Nutrition 33(1) : 80-85, 2000)

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