Antioxidative Effects of Diarylheptanoids from Alnus hirsute

물오리나무에서 분리된 Diarylheptanoid의 항산화작용

  • Published : 2000.04.01

Abstract

Four diarylheptanoids oregonin, hirsutanonol, 1,7-bis- (3,4-dihydroxyphenyl)-heptane-5-O-$\beta$-D-xylopyanoside and 1,7-bis-(3,4-dihydroxyphenyl)-heptane-5-0-$\beta$-D-glucopyranoside isolated from Alnus hirsuta were evaluated for their antioxidative effects with 1,1-diphenyl-2-picrylhydrazyl (DPPH) radical and lipid peroxidation generation system mediated by addition of $H_2O$$_2$and/or Fe$^{2+}$ to rat liver homogenate. All these diarylheptanoids showed significant inhibitory activities against the DPPH radical and demonstrated strong activities in preventing the lipid peroxidation induced by $H_2O$$_2$.>.

Keywords

References

  1. 한국식물명고
  2. 小學館 v.3 中藥大辭典
  3. Korean Folk Medicine Lee,S.J
  4. Alnus hirsuta Turcz,Mokuzai gakkaish v.19 Isolation of Hirsutanonol and Hirsutenone,Two new diarylheptanoids from the green bark of keyama-hannoki Terazawa,M.,Okuyama,H.;Miyake,M
  5. J.C.S.Chem,Comm v.649 Structure of oregonin a Natural Diarylheptanoid Xyloside Karches,J.J.,Laever,M.L.,Barofsky,D.F.;Barofsky,E.
  6. Microphylla,Phytochemistry v.31 Hirsunin, an ellagitannin with a diarylheptanoid moiety from Alnus hitsuta var Lee,M-W.,Tanaka,T.,Nonaka,G.;Nishioka,I
  7. v.40 Diarylheptanoids,flavinoids,Stibenoids,Sesqu-iterpenoids and a phenanthrene from Alnus maximowiczii,Phytochmistry Tori,M.,Hashimoto,A.,Hirose,K.;Asakawa,Y.
  8. v.46 Three new diarylheptanoid glycosides from Alnus japonica,Chem.Pharm.Bull Wada,H.,Tachibana,H.Fuchino,H.;Tanaka,N.
  9. v.13 Four New Diarylheptanoid Glycosides from Alnus Rubra Bark Nat.Prod.Lett Gonzalez-Laredo,R.F.Chem,J.,Karchesy,Y.M.;Karchesy,J.J
  10. Bull.Chem.Soc.Japan v.44 Chemical constituents of the male Flower of Alnus Pendula(Betulaceae) Suga,T.Iwata,N.;Asakawa,Y.
  11. The isolation and structure of flavonoids and stilbenes,Bull.Chem.Soc.Japan v.44 Chemical constituents of Alnus sieboldiana(Betulaceae)Ⅱ Asakawa,Y
  12. Chem.Nat,Comp v.10 Quercetin-3-sophoroside from Alnus glutinosa and Fraxinus lanceolata Pollens Stikhin,V.A.,Ban'kovskii,A.i.Glyzin,V.I.;Kir'yanova,I.A
  13. Yakhak Hoeji v.43 Flavonoids from the Leves of Alnushirsuta Lee,M-W.,Jeong,D-W.,Lee,Y-A.,Park,M-S.;Toh,S-H
  14. Yakhak Hoeji v.44 Flavonoids from the Leves of Alnus Maximowiczii Call Ahn,K-W.,Toh,S.-H.,Jeong,D,-W.,Kim,J.-S.,Cho,S,-M.;Lee,M,-W
  15. Diarylheptanoids with In vitro Inducible Nitric Oxide Synthesis Inhibitory Activity from Alnus hirsuta Planta Med.in press Lee,M.W.Kim.N.Y.,Park,M.S.Ahn.K.H.,Toh,S.H.,Hahn,D.R.,Kim,Y.C;Chung,H.T
  16. Bark of Alnus hirsuta var,Sibirica,Biol.pharm.Bull in press Inhibition of Cyclooxy genase-2 Expression by Diarylheptanoids from the Lee,M.W.,Kim,J.H.,Jeong,D.W.Ahn,K.H.Toh,S.H.;Surh,Y.J
  17. chung-Ang J.Pharm.Sci v.12 Effects of Orgonin,diarylheptanoid derivative from plant on antitumor Lee,D.I.,Chang,J.k.,Lee.M.W.;Hong,S.G
  18. v.23 Diarylheptanoids from the Leaves of Alnus hirsuta Turcz,Arch.Pharm.Res Lee,M-W.,Park,M,S.,Jeong,D.W.Kim,K.H;Toh,S.H
  19. Effects of tannins and related polyphenols on superoxide anion radical and on 1,1 diphenyl1-2-picrylhylhydrazyl radical ,Chem.Pharm.Bull v.37 Effects of the interaction of tannins with co-existing substances Ⅵ Hatano,T.,Edamatsu,R.,Hiramatsu,M.,Mori,A.,Fujita,Y.,Yasuhara,T.,Yoshida,T.;Okuda,T.
  20. Anal.Biochem v.95 Assay for lipid peroxide in animal tissues by thiobarbituric acid reaction Ohkawa H.Ohishi N.,Yagi K.
  21. Natural Medicines v.51 Antiperoxidation Activity of Traditional Chinese Prescriptions and their Main Crude Drugs In vitro Yokozawa,T.,Dong,E.,Liu,Z.W;Oura,H