Archives of Pharmacal Research

The Pharmaceutical Society of Korea (대한약학회)
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Aromatase Inhibitors from Isodon excisus var. coreanus

  • Jeong, Hyeh-Jean (PCRPS and Department of Medicinal Chemistry and Pharmacognosy, College of Pharmacy, University of Illinois at Chicago) ;
  • Chang, Leng-Chee (PCRPS and Department of Medicinal Chemistry and Pharmacognosy, College of Pharmacy, University of Illinois at Chicago) ;
  • Kim, Ho-Kyoung (College of Pharmacy, Chung-Ang University) ;
  • Kim, Il-Hyuk (College of Pharmacy, Chung-Ang University) ;
  • A.Douglas Kinghorn (PCRPS and Department of Medicinal Chemistry and Pharmacognosy, College of Pharmacy, University of Illinois at Chicago) ;
  • John M.Pezzuto (PCRPS and Department of Medicinal Chemistry and Pharmacognosy, College of Pharmacy, University of Illinois at Chicago)
  • Published : 2000.06.01
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Abstract

The diethyl ether extract of isodon excisus var. coreanus exhibited significant inhibitory activity in aromatase assay. Bioactivity-guided fractionation of the extract led to the isolation of three active compounds: inflexin(ent-1${\alpha}$-hydroxy-3${\beta}$,6a-diacetoxykau r-16-en-11,15-dione) (1), ursolic acid (2), and ursolic acid 3-O-acetate (3).

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