Archives of Pharmacal Research
- Volume 23 Issue 2
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- Pages.112-115
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- 2000
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- 0253-6269(pISSN)
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- 1976-3786(eISSN)
Synthesis of 4,6-Dichloro-3-[(1-N-Arylaminocarbonyl)-Hydrazono]- 1,3-Dihydro-Indole-2-One as a Potential NMDA Receptor Glycine Site Antagonist
- Hwang, Ki-Jun (Department of Chemistry, and Research Center of Bioactive Materials, College of Natural Science, Chonbuk National University) ;
- Lee, Tae-Suk (Hambak kwan, Myong Ji University)
- Published : 2000.04.01
Abstract
A synthetic procedure for the preparation of indole-2,3-dione derivatives 6 as a potential NMDA receptor glycine site antagonist with improved pharmacological profile compared with 2-carboxyindole derivative 5, starting from readily available 3,5-dichloroaniline (7), is described.