Archives of Pharmacal Research
- 제23권2호
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- Pages.104-111
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- 2000
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- 0253-6269(pISSN)
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- 1976-3786(eISSN)
Synthesis and Characterization of Stereospecific 1-Propargyl-2-(dimethoxymethyl)-1- cyclohexanols
- Lin, Juwhan (Dept. of Polymer Science and Engineering, Chungnam National University) ;
- Kim, Sang-Il (Dept. of Polymer Science and Engineering, Chungnam National University) ;
- Lee, Seung-Yong (Dept. of Polymer Science and Engineering, Chungnam National University) ;
- Kim, Yong-Hyun (College of Pharmacy, SungKyunKwan University) ;
- Lee, Kee-Young (College of Pharmacy, SungKyunKwan University) ;
- Oh, Chang-Young (College of Pharmacy, SungKyunKwan University) ;
- Ham, Won-Hun (College of Pharmacy, SungKyunKwan University)
- 발행 : 2000.04.01
초록
Stereochemical isomers with hydroxy groups were synthesized by reacting 2-(dimethoxy-methyl)cyclohexanone with propargylmagnesium bromide. The stereo chemical structures were identified by NMR spectral interpretation and the geometry optimization. To assist the NMR interpretation, geometry optimization based on semi-empirical AM1 and PM3 methods was applied. Throughout this study, the structures of the two isomers were all determined and