KSBB Journal

The Korean Society for Biotechnology and Bioengineering (한국생물공학회)
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Effect of Platycodon grandiflorum A. DC Extract on the Bronthus Diseases Bacteria

도라지[Platycodon grandiflorum A. DC] 추출액에 따른 기관지 질환 세균에 미치는 효과

  • 이인순 (대구대학교 공과대학 생물공학과) ;
  • 최명철 (대구대학교 공과대학 생물공학과) ;
  • 문혜연 (대구대학교 공과대학 생물공학과)
  • Published : 2000.04.01
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Abstract

This study was pe바ormed to observe the effects of Platycodon grandiflorum A. DC (3 years) extracts on the bronchus d diseases bacteria(Mycobacterium sp., K. pneumoniae, F. nucleatum, S. aureus, C. diphtheriae, S. pygogenes and N N. gonorrhoeae) and fungi(A. fumigatus). Platycodon grandiflorum A. DC was extracted by ethanol, water, ethyl ether and p petroleum ether. The extraction rates of Platycodon grandiflorum A. DC were identified as 71.8%, 100%, 15.4% and 14.1% i in each extract solution. Each extract solution was injected into culture media with several concentrations and then the b bacteria cell growth was investigated during 32 hours. As a result, the antimicrobial activities of extracts from ethyl ether and p petroleum ether were excellent. Among several concentrations, the percentage of bacteria cell growth inhibitions were observed to be from 0.06% to 0.14%. The rates of antimicrobial activities were over 70%. The degree of cell growth | inhibition of each bacteria was appeared in the order of ethyl ether > petroleum ether > water > ethanol.

도라지에 H2O, ethanol, ethyl ether와 petroleum ether를 용매로 하여 추출한 시료를 기관지질환 유발세균(S. aureus, C. diphtheriae, Mycobacterium sp. F. nucleatum, A. funicatus, K. pneumoniae, S. pyogenes N. gonorrhoeae)에 투여한 결과 ethyl ether, petroleum ether, H2O와 ethanol의 순으로 항균력이 우수하다는 것이 판명되었다. 특히, ethyl ether에 의한 도라지 추출물의 항균력이 80%이상 뛰어난 효과를 나타내었다. 우수한 항균력을 가지는 도라지 추출물의 농도는 30mg부터 30%이상의 억제작용을 보였으며 70mg에서 70%이상의 세포 성장이 저해되는 현상을 관찰하였다. 기관지 질환 유발세균에 대한 도라지의 효과는 대조구에 비해 70%이상의 탁월한 항균효과가 있는 것으로 확인되었다.

Keywords

References

  1. Kor. J. Pharmacog. v.5 Pharmacological studieson platycodiradix Eun Bang Lee
  2. J. Korean Soc. Food Nutr. v.22 no.5 Effect of the feeding Platycodon grandiflotum and codonopsis lanceolata on the lipid components of serum and liver in rats S. Y. Kim;H. S. Kim;H. S. Y.;S. Y. Chung
  3. J. of the Kor. Agriculture Chemistry and Biotechnoloy v.40 no.2 Chemical compositions of platycodon grandiflorus Chung J. H.;Shin P. G.;Cho S. H.
  4. J. of the Kor. Agriculture Chemistry and Biotechnoloy v.40 no.2 Pharmaceutical substances of platycodon grandiflorus Chung J. H.;Shin P. G.;Cho S. H.
  5. Kor. J. Pharmacog v.6 no.1 Pharmaceutical studies on Condonopsis lanceolate C. H. Kim;M. H. Chung
  6. Phytology S. I. Lee
  7. Kor. J. Pharmacog. v.3 Analysis of componets of saponin from Ginseng, platycodon and Japanese touchwood H. D. Kim;J. W. Lee
  8. J. Korean Soc. Food Nutr. v.21 no.1 Screening of antimicrobial activity for medicinal herb extracts U. Y. Park;D. S. Chang;H. R. Cho
  9. KOREAN J. FOOD SCI. TECHNOL. v.30 no.1 Effect of platycodon grandiflotum DC extract on the growth of cancer cell lines Ji-Young Lee;Woo-Ik Hwang;Seung-Taik Lim
  10. Korean J. Ginseng Sci. v.19 no.3 Anticancer effect of the hydrolyzed monogluco ginsenoside of total saponin from ginseng leaf K. S. Im;H. Y. Chung;N. K. Je
  11. The method of natural chemical product O. S. Woo
  12. J. KOREAN SOC. FOOD NUTR. v.18 no.1 Studies on the Extraction Condition of Ssang Wha Tea Kwang Yun Cho
  13. J. Korean Soc. Food Nutr. v.25 no.6 Effect of Platycodon grandiflotum extract on blood gloucose and lipid composition in alloxan induced hyperglycemic rats N. J. Sung;S. J. Lee;J. H. Shin;Y. C. Chung
  14. Plant Physiol. v.108 Induction of anthocyanin accmulation by cytolinins in Arabidopsis thaliana Jill Deikman;Philip E. Hammer
  15. Agric. Chem. Biotechnol. v.41 no.8 Fungical Activity of Oriental Medicinal Plant Extracts against Plant Pathogenic Fungi Jae-Ki Yoo;Jeong-Hyun Kwon;Sung-Suk Lee;Young-Joon Ahn