Journal of Microbiology and Biotechnology

The Korean Society for Microbiology and Biotechnology (한국미생물·생명공학회)
권호 표지

Biocontrol Activity of Pseudomonas cepacia AF2001 and Anthelmintic Activity of Its Novel Metabolite, Cepacidine A

  • Lee, Chul-Hoon (Department of Mdical Genetics,College of Medicine, Hanyang University) ;
  • Kempf, Hans-Joachim (Biocontrol Team, BU Fungicides, Novartis Crop Protection AG) ;
  • Lim, Yoong-Ho (Department of Applied Biology and Chemistry, Konkuk University) ;
  • Cho, Youl-Hee (Department of Mdical Genetics, College of Medicine,Hanyang University)
  • Published : 2000.08.01
Download PDF
⟨ Previous Next ⟩

Abstract

Cepacidine A was previously isolated as a novel antifungal antibiotic from the culture broth of Pseudomonas cepacia AF2001. It exhibits a potent in vitro antifungal activity against various plant pathogenic fungi, such as Plasmopora veticola on grapes, Septoria nodorum and Fusarium culmorum on wheat, as well as Colletotrichum lagenarium on cucumbers. Accordingly, this study was conducted to evaluate the potential crop protection activity of strain P. cepacia AF2001. The strain was tested in semi-greenhouse biocontrol assays, and showed an excellent biological activity against Pythium ultimum in cotton and cucumbers; however, only a minor activity against Rhizoctonia aolani in cotton was observed. Furthermore, the nematodes Haemonchus contortus and Trichostrongylus only exhibited a moderated activity in the in vitro larval development assay with no activity in the in vivo animal model.

Keywords

References

  1. J. Clin. Microbiol v.33 Burkholderia cepacia and cystic fibrosis Butler, S. L.;C. Doherty;J. Hughes;J. Nelson;J. R. Govan
  2. J. Parasitol v.77 Concurrent infections with the ruminant nematodes Haemonchus contortus and Trichostrongylus colubriformis in jirda Conder, G. A.;S. S. Johnson;P. M. Guimond;D. L. Cox;B. L. Lee
  3. Proc. Natl. Acad. Sci. USA v.92 Molecular mechanisms of defense by rhizobacteria against root diseases Cook, R. J.;L. S. Thomashow;D. M. Weller;D. Fujimoto;M. Mazzola;G. Bangera;D. Kim
  4. Benefits and Risks in Introducing Biocontrol Agents Pseudomonads as biocontrol agents of diseases caused by soil-borne pathogens Defago, G.;C. Keel;H. Hokkanen;J. Lynch(eds.)
  5. Eur. J. Plant Pathol v.104 Suppression of pre-and post-emergence damping-off in corn by Burkholderia cepacia Hebbar, K. P.;M. H. Martel;T. Heulin
  6. Emerg. Infect. Dis v.4 Agricultural use of Pseudomonas cepacia: A threat to human hralth? Holmes, A.;J. Govan;R. Goldstein
  7. Multitrophic Interactions in Terrestrial Systems Interactions between beneficial soil bacteria and root pathogens: Mechanisms and ecological impact Keel, C.;G. Defago;A. C. Gange;V. K. Brown(eds.)
  8. Mol. Plant-Microbe Interact v.5 Suppression of root diseases by Pseudomonas fluorescens CHA0: Importance of the bacterial secondary metabolite 2,4-diacetylphloroglucinol Keel, C.;U. Schnider;M. Maurhofer;C. Voisard;J. Laville;U. Burger;P. Wirthner;D. Haas; G. Defago
  9. FEMS Microbiol. Ecol v.27 Impact of Pseudomonas fluorescens strain CHA0 and a derivative with improved biocontrol activity on the culturable resident bacterial community on cucumber roots Natsch, A.;Ch. Keel;N. hebecker;E. Laasik;G. Defago
  10. Can. J. Microbiol v.40 production of 2,4-diacetylphoroglucinol by biocontrol agent, pseudomonas fluorescens Pf-5 Nowak-Thompson, B.;S. J. Gould;J. Kraus;J. E. Loper;
  11. J. Microbiol. Biotechnol v.9 Immunosuppressive activity of cepacidine A, a novel antifungal antibiotic peoduced by Pseudomons cepacia Lee, C.-H.;J.-W. Suh;Y.-H. Cho
  12. J. Antibiot v.47 Cepacicine A, a novel antifungal antibiotic prosuced by Pseudominas cepacia. I. Taxonomy, isolation and biological activity Lee, C.-H.;S. Kim;B. Hyun;J.-W. Suh;C. Yon;c. Kim;Y. Lim;C. Kim
  13. J. Antibiot v.47 Cepacidine A, a novel antifungal antibiotic produced by POseudomonas cepacia. II. Physico-chemical properties and structural elucidation Lim, Y.;J.-W. Suh;S. Kim;B. Hyun;C. Kim;C.-H. Lee
  14. Am. J. Vet. Res v.55 Effectiveness of doramectin for treatmrnt of experimentally induced gastrointestinal tract larval nematode infections in calves Yazwinski, T. A.;H. Featherston;C. Tucker