Journal of Chest Surgery

  • 제33권8호
  • /
  • Pages.613-622
  • /
  • 2000
  • /
  • 2765-1606(pISSN)
  • /
  • 2765-1614(eISSN)
대한심장혈관흉부외과학회 (The Korean Society for Thoracic and Cardiovascular Surgery)
권호 표지

DelNido 심정지액의 심근보호효과

Evaluation of Cardioprotective Effects of DelNido Cardioplegia

  • 우석정 (동아대학교 응급의학과) ;
  • 장봉현 (경북대학교 의과대학 흉부외과학교실) ;
  • 김규태 (경북대학교 의과대학 흉부외과학교실)
  • 발행 : 2000.08.01
PDF 다운로드
⟨ 이전 논문 다음 논문 ⟩

초록

Background: The aim of this study is to define the cardioprotective effects(functional and metabolic) of newly developed DelNido cardioplegic solution(containing plasma solution, mannitol, magnesium and lidocaine). Material and Method: This study assessed the function of rat hearts after itermittent infusion of DelNido cardioplegia with different preserving methods(Air or Icebox) for 2hours and perfusing the hearts on a Langendorff apparatus. Heart rate, left ventricular developed pressure(LVDP) and coronary flow, were measured at pre-ischemic, post-reperfusion 15min, 30min and 45min. Coronary flow was standardized to dry heart weight. Each weight was weighted to calculate water content. Creatine kinase-MB isoenzyme release was measured and ultrastructural assessment was done with electron microscopes. Result: DelNido group was better than St, Thomas group and Icebox group was better than Room-air group. Conclusion: DelNido cardioplegia have better myocardial protective effects than St. Thomas cardioplegia when they were preserved in the Room-air. But we can not tell the difference between Delnido cardiplegia with Air preserving method and St. Thomas cardioplegia with Icebox.

키워드

참고문헌

  1. Lancet v.2 Elective cardiac arrest Melrose DG;Dreyer B;Bentall HH;Becker JBE
  2. J Surg Res v.24 Beneficial effects of potassium cardioplegia during intermittent aortic cross-clamping and reperfusion Wright RN;Livitsky S;Holland C;Feinberg H
  3. J thorac Cardiovasc Surg v.77 A proposed solution to the cardioplegic controversy Buckberg GD
  4. Circulation v.57;58 The role of hypothermia in the past, present and future management of heart disease Bigelow WG
  5. J. Mol Cell Cardi v.11 Ultrastructural, functional, and biochemical criteria for estimation of reversibility of ischemic injury: a study on the effects of global ischemia on the isolated dog heart Jutta Schaper J;Mulch B;Winkler B;Wchaper W
  6. Cardiovasc Res v.31 Amelioration of ischemia/reperfusion injury in isolated rat hearts by the ATP-sensitive potassium channel opener BMS-180448 Monticello TM;Sargent CA;Mcgill JR;Barton DS;Grover GJ
  7. Surgery v.74 Functional, metabolic and morphological effects of potassium induced cardioplegia Gay WA;Ebert PA
  8. J Mol Cell Cardiol v.18 Magnesium in cardiac energy metabolism Garfinkel LG;Altschuld, Garfinkel D
  9. J Gen Physiol v.88 Blockade of current through single calcium channels by Ca2+ Mg2+ and Ca2+ Lansman JB;Hess P;Tsien RW
  10. Biophy J v.55 Multiple conductance state of the purified calcium release channel complex from skeletal sarconplasmic reticulm Liu Q;Lai A;Rousseau E;Hones RV;Meissner, G
  11. J Thorac Cardiovasc v.98 The effect of calcium and magnesium in hyperkalemic cardioplegic solutions onmyocardial preservation Geffin GA;Love TR;Hendren WG(et. al.)
  12. Thoraeic and Cardiovascular surgery(4th ed) The safety of blood cardioplegia at 4°C and a simple system for its delivery Robertson JM;Buckberg GD;Vinten Johansen J(et. al.);Glenn WWL(ed)
  13. Circulation v.66 Failure of blood cardioplegia to protect myocardium at lower temperatures Magovern GJ;Jr Falherty JT;Gott VL(et. al.)
  14. J Thorac Cardjiovas Surg v.105 Ventricular function after normothermic versus hypothermic cardioplegia Yau TM;Ikonomidis JS;Weisel RD(et. al.)
  15. J Thorac Cardiovasc Surg v.45 The relationship between myocardial temperature and recovery after experimental cardioplegic arrest Rosenfeldt FL
  16. J Thorac Cardiovasc Surg v.93 Clinical comparisions of methods of myocardial protection Daily PO;Pfeffer TA;Wisniewski JB
  17. Ann thorac Surg v.33 Chnical evaluation of the relative effectiveness of multidose crystalloid and cold blood patassium cardioplegia in coronary artery bypass surgery Roberts AF;Moran JM;SAnders JH(et.al.)
  18. Textbook of clinical cardioplegia Blood cardioplegia-experince with prolonge cross-clamping Cunningham JN;Catinell FP;Spencer FC;Engelman RM;Levitsky SA
  19. Textbook of clinical cardioplegia Blood versus crystalloid cardioplegia Fabiani JN;Perier P;Chelly J(et. al.);ENgelman RM;Levistsky SA
  20. Ann Thorac Surg v.33 Myocardial protection with cold blood potassium cardioplegia during prolonged aortic cross-clamping Catinella FP;Cunningham JN;Adams PX(et.al.)
  21. Ann Thorac Surg v.29 Clinical experience with cold blood as the vehicle for hypothermic potassium cardioplegia Barner HB;Kaiser GC;Code JE(et. al.)
  22. J Thorac Cardiovasc Surg v.88 A climcal trial of blood and crystalloid cardioplegia Fremes SE;Christakis JT;Weisel RD(et. al.)
  23. J Thorac Cardiovasc Surg v.86 Comparison of distribution of coronary stenosts of blood and asanguinous cardioplegic solution Robertson JM;Buckberg GD;Vinten-Hohansen J;Leaf JD
  24. Ann Thorac Surg v.50 Oxygen cardioplegia blood is a many splendored thing Buckberg GD
  25. Cardiac Surg of the neonate and infant Myocardial preservation in the immature heart Castned AR;Jonas RA;Mayer E;Hanley FL
  26. J Thorac Cardiovasc Surg v.81 Protection of the myocardium during ischemic arrest: Dose-response curves for procaine and lignocaine in cardioplegia solutions Hearse DJ;O'Brien K;Biaimbridge MV
  27. Ann Thorac Surg v.39 Intraoperative myocardial protection, a comparison of bllod and asanguineous cardioplegia Codd JE;Barner HB;Pennington DG(et. al.)
  28. Cardiovasc Res v.22 Tole of red blood cells in the coronary microcirculation curing cold blood cardioplegia Sakai A;Mija J;Sohara Y(et. al.)
  29. CIr Res v.34;35 Structural changes in myokcardium during acute ischemia Jennings RB;Ganote CE
  30. Circulation v.74 Early function of cardiac homograft: relationship to hemodynamic in the donor and length of the ischemic period Trento A;hardesty RL;Griffith BP;Kkormos RL;Bahnson HT