The Journal of Internal Korean Medicine (대한한방내과학회지)

The Society of Internal Korean Medicine (대한한방내과학회)
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Effects of Sasim-tang Water Extract on Blood Pressure and Regional Cerebral Blood Flow Volume in Rats

사심탕(瀉心湯)이 백서(白鼠)의 혈압(血壓) 및 국소(局所) 뇌혈류량(腦血流量)에 미치는 영향(影響)

  • Lee, Kwang-Gyu (Dept. of Pathology, Woo-Suk Univ.) ;
  • Moon, Byung-Sun (Dept. of Cardiovascular Internal Medicine, College of Oriental Medicine, Won-kwang Univ.) ;
  • Lee, In (Dept. of Cardiovascular Internal Medicine, College of Oriental Medicine, Won-kwang Univ.) ;
  • Kim, Jin-Su (Dept. of Pathology, Woo-Suk Univ.) ;
  • Lee, Key-Sang (Dept. of Cardiovascular Internal Medicine, College of Oriental Medicine, Won-kwang Univ.)
  • 이광규 (우석대학교 한의과대학 병리학 교실) ;
  • 문병순 (원광대학교 부속 한방병원 심계내과학교실) ;
  • 이인 (원광대학교 부속 한방병원 심계내과학교실) ;
  • 김진수 (우석대학교 한의과대학 병리학 교실) ;
  • 이기상 (원광대학교 부속 한방병원 심계내과학교실)
  • Published : 2000.11.30
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Abstract

Objective : The purpose of this study was to investigate the effects of Sasim-tang water extract on the cardiovascular systems including changes of blood pressure and regional cerebral blood flow volume (rCBF) in male Sprague-Dawely rats. Methods : The changes of blood pressure were recorded by data acquisition system composed of MacLab and Macintosh computer. The changes of rCBF were observed by Laser-Doppler flowmetry through a opened cranial window. Results : 1. The changes of blood pressure was not affected by Sasim-tang extract intravenous injection in rats. 2. After pretreatment with propranolol(3mg/kg), L-NNA(10mg/kg) and 000(10mg/kg), the changes of blood pressure was not affected by Sasim tang extract intravenous injection in rats. 3. The changes of rCBF was increased in dose-dependent manner by Sasim-tang extract intravenous injection in rats. 4, After pretreatment with propranolol(3mg/kg), ODQ(10mg/kg) and L-NNA(10mg/kg), rCBF was significantly decreased in dose- dependent manner by Sasim-tang extract intravenous injection in rats. Conclusions : These results suggest that Sasim-tang was related to the regulation of the sympathetic nerve system, nitric oxide synthesis and synthesis of cyclic GMP.

Keywords

References

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