The Journal of Internal Korean Medicine (대한한방내과학회지)

The Society of Internal Korean Medicine (대한한방내과학회)
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Effects of Bupleuri Radix on Rat Hepatic MAO by Common Bile Duct Ligation and Taurocholate Load after Common Bile Duct Ligation

시호(柴胡)가 총담관결찰 및 taurocholate 부하(負荷) 흰쥐 간의 MAO 활성에 미치는 영향

  • Kim, Seong-Mo (Department of internal Medicine, College of Oriental Medicine, Kyungsan University) ;
  • Wang, Wu-Hao (Department of internal Medicine, College of Oriental Medicine, Kyungsan University) ;
  • Park, Jae-Hyun (Department of internal Medicine, College of Oriental Medicine, Kyungsan University)
  • 김승모 (경산대학교 한의학과 간계 내과학 교실) ;
  • 왕오호 (경산대학교 한의학과 간계 내과학 교실) ;
  • 박재현 (경산대학교 한의학과 간계 내과학 교실)
  • Published : 2000.10.30
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Abstract

Object : This study was carried out to examine the effect of Bupleuri Radix on experimental cholestasis, and make clear apart of this mechanism. Methods : Two models of common bile duct ligation group and taurocholate load group after common bile duct ligation were induced, and Bupleuri Radix extract was taken orally for 14 days. In the 1, 2, 4, 7 and 14 days after treatment, the mitochondrial and microsomal monoamine oxidase(MAO) A and B activities in liver were measured. Results : The mitochondrial MAO A and B activities increased in both Blupleuri Radix treated group after common bile duct ligation and Blupleuri Radix treated group after taurocholate load and common bile duct ligation. MAO A increased in Blupleuri Radix treated group after taurocholate load and common bile duct ligation, and MAO B increased in Blupleuri Radix treated group after common bile duct ligation. The microsomal MAO A activities increased in both Blupleuri Radix treated group after common bile duct ligation and Blupleuri Radix treated group after taurocholate load and common bile duct ligation. Conclusion : According to the result, it is consider that Blupleuri Radix not only improves cholestatis in liver, but also decreases a genetic synthesis of taurocholic acid.

Keywords

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