THE JOURNAL OF KOREAN ORIENTAL ONCOLOGY (대한한방종양학회지)

Korean Association of Traditional Oncology (대한암한의학회)
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Study on toxicity, anti-cancer and NK cell activity of Lateril oil

행인 제제의 독성 및 항암효과의 자연살해세포 활성에 미치는 효과

  • Shim, Bum-Sang (Department of Oriental Pathology, College of Oriental Medisine, Kyung Hee University) ;
  • Choi, Seung-Hoon (Department of Oriental Pathology, College of Oriental Medisine, Kyung Hee University) ;
  • Park, Jai-Kyung (Immunology Research laboratory, Research Institute of East-West Medicine, Kyung Hee University Medical Center,Department of Molecular Genetics, Institute of Asan Life Science)
  • 심범상 (경희대학교 한의과대학 병리학교실) ;
  • 최승훈 (경희대학교 한의과대학 병리학교실) ;
  • 박재경 (경희의료원 동서의학연구소 면역학연구실)
  • Published : 2000.12.30
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Abstract

In this experiment, we examined the the effect of Laetrile Oil to the immune system and tried to disclose the anti-cancer mechanism of this. The result is listed as below. 1. After per-os, sub-cutaneous and into the peritoneal injection of Laetrile Oil to the SPF mice, the LD50 is above 5000mg/kg at even group. 2. Mean survival days of mice treated with laetril oil, after S-180 cells transplantation into the peritoneal cavity decreases 1.5 days(-6.8%) compared with the Mean survival days of the control group(22days.) 3. Effects of laetril oil on natural killer cell activity at Effector/Target Cell Ratio with 100:1, 50:1, 10:1 into methotrexate-pretreated mice is like this.: Compared with $29.22\pm12.7\%$ Cytotoxicity of the control group, sample group's Cytotoxicity had $38.83{\pm}12.5%$ of meaningful acrease. At 100:1 Effecr/Target Cell Ratio. At 50:1 Effector/Target Cell Ratio, control group has $20.02{\pm}9.6%$ Cytotoxiciy and sample group had $31.53{\pm}13.4%$ Cytotoxicity. At 25:1 Effector/Target Cell Ratio control group has $13.60{\pm}6.6%$ Cytotoxicity and sample group had $20.81{\pm}9.8%$ Cytotoxicity According to the above results, the Laetrile Oil represents nontotoxic to a SPF mice. non-effective to transplantable Sarcoma 180 tumors, and activaion in NK cell activity.

Keywords

References

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