Herbal Formula Science (대한한의학방제학회지)

The Korean Medicine Society for the Herbal Formula Study (대한한의학방제학회)
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Pharmacological Activities of the Polysaccharide extracted from Phellinus linteus

상황버섯으로부터 분리한 고분자 다당류의 약리활성

  • Lee Eun-Sook (Department of preparatory oriental medicine, Kyungsan university) ;
  • Seo Bu-Il (Department of Herbology College of oriental medicine Kyungan University)
  • 이은숙 (경산대학교 한의예과) ;
  • 서부일 (경산대학교 한의과대학 본초학교실)
  • Published : 2000.12.05
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Abstract

To examine the pharmacological activity of the polysaccharide extracted from phellinus linteus, we obtained the polysaccharide treated by the alkali and hot water, molecular weights of hot water was 10kD and 225 kD. Anticomplementary activity were highly observed in hot water fraction than alkali fraction. The tumor inhibition ratio of the polysaccharide extracted by hot water and alkali of Phellinus linteus against sarcoma 180 were 72.5% and 67.6%, respectively. These results suggest that protein bound polysaccharides extracted by a hot water and alkali of Phellinus linteus were similar to the pharmacological activities and chemical properties.

상황버섯 자실체의 열수 및 알칼리 추출다당류에 대한 약리 효과는 다음과 같다. 1. 분자량은 10kD 부근에서 주를 이루고 있었으며, IR은 다당류의 전형적인 peak 흡수대를 나타냈다. 2. 항암 활성과 보체 활성에 있어서는 열수추출 다당류에서 높게 나타났으며, 지질 과산화 저해능은 알칼리 추출 및 열수 추출 분획에서 각각 71.3%와 55.8%의 저해율을 나타내었다. 상기와 같은 결과를 종합하여 볼 때 상황버섯 자실체의 열수 및 알칼리 추출물은 당과 단백질로 구성된 단백 다당류였으며, 열수 추출과 알칼리 추출에 의한 약리활성 정도는 유사한 것으로 조사되었다.

Keywords

References

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