Journal of the Korean Association of Oral and Maxillofacial Surgeons
- Volume 26 Issue 1
- /
- Pages.24-39
- /
- 2000
- /
- 2234-7550(pISSN)
- /
- 2234-5930(eISSN)
EVALUATION OF THE INTERFACES BETWEEN IMPLANTS AND REGENERATED BONE USING BONE MORPHOGENETIC PROTEIN AND DEMINERALIZED FREEZE-DRIED BONE
임플란트 매식시 골형성단백질 및 탈회동종골 사용에 따른 골재생 및 계면에 대한 연구
- Kang, Sang-Gyu (Dept. of Oral and Maxillofacial Surgery, College of Dentistry, Seoul National University) ;
- Lee, Jong-Ho (Dept. of Oral and Maxillofacial Surgery, College of Dentistry, Seoul National University) ;
- Kim, Myung-Jin (Dept. of Oral and Maxillofacial Surgery, College of Dentistry, Seoul National University)
- Published : 2000.02.28
Abstract
Various methods and graft materials have been used to fill in the defect adjacent to the implants and considered as clinically acceptable. But it is not clear whether the regenerated bone increases the implant-bone contact and supports the implant. The purpose of this study is to evaluate regenerated bone surrounding implants using bone morphogenetic protein(BMP) and demineralized freeze-dried bone(DFDB), and the interfaces between implants and regenerated bone. bBMP was extracted and partially purified from the bovine bone matrix using heparine chromatography. Demineralized freeze-dried bone was made from the dog. Inactive insoluble collagenous bone matrix(IBM) of dog was used as carrier of bBMP. Interfaces of titanium coated epoxy resin implants were processed for demineralized section for transmission electron microscopy(TEM) and those of screw type implants were for nondemineralized section for light and fluoromicroscopic examination. Implants were inserted in the inferior border of mandible of adult dogs and artificial bony defects(
Keywords