Journal of Pharmaceutical Investigation
- Volume 30 Issue 1
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- Pages.47-50
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- 2000
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- 2093-5552(pISSN)
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- 2093-6214(eISSN)
Microcapsules for Stabilization of Lactic Acid Bacteria
유산균을 안정화시킨 마이크로캅셀의 제조 및 평가
- Jeon, Hong-Ryeol (Central Research Institute, Il Yang Pharm. Co., Ltd.) ;
- Park, Dong-Woo (Central Research Institute, Il Yang Pharm. Co., Ltd.) ;
- Lee, Young-Jae (Central Research Institute, Il Yang Pharm. Co., Ltd.) ;
- Kwon, Suk-Hyung (College of Pharmacy, Chung-Ang University) ;
- Choi, Young-Wook (College of Pharmacy, Chung-Ang University)
- 전홍렬 (일양약품(주) 중앙연구소) ;
- 박동우 (일양약품(주) 중앙연구소) ;
- 이영재 (일양약품(주) 중앙연구소) ;
- 권석형 (중앙대학교 약학대학) ;
- 최영욱 (중앙대학교 약학대학)
- Published : 2000.03.20
Abstract
A new technique has been developed for the preparation of Lactobacillus microcapsules to enhance the stability against high temperature, humidity, gastric acid and bile acid. Employing fluidized bed coating, primary sub-coating was processed in non-organic solvent system, so that Lactobacillus did not directly contact with organic solvent. Secondary enteric-coating was processed in organic solvent with low temperature