한국약용작물학회지 (Korean Journal of Medicinal Crop Science)

  • 제8권4호
  • /
  • Pages.291-296
  • /
  • 2000
  • /
  • 1225-9306(pISSN)
  • /
  • 2288-0186(eISSN)
한국약용작물학회 (The Korean Society of Medicinal Crop Science)
권호 표지

구기자 부위별 추출물이 흰쥐 비장세포의 증식에 미치는 영향

Effects of Extracts from Various Parts of Lycium chinense Mill. on the Proliferation of Mouse Spleen Cells

  • 박종상 ((주) 마이크로플랜츠 중앙연구소) ;
  • 박종대 (한국인삼연초연구원) ;
  • 이봉춘 (충남농업기술원 청양구기자시험장) ;
  • 최강주 (한국인삼연초연구원) ;
  • 라상욱 (충남농업기술원 청양구기자시험장) ;
  • 장기운 (충남대학교 농화학과) ;
  • Park, Jong-Sang (Microplants Co., Ltd. R&D Center) ;
  • Park, Jong-Dae (Korea Ginseng & Tobacco Research Institute) ;
  • Lee, Bong-Chun (Chungyang Boxthorn Experimental Station, Chungnam Agricultural Research and Extention) ;
  • Choi, Kang-Ju (Korea Ginseng & Tobacco Research Institute) ;
  • Ra, Sang-Wook (Chungyang Boxthorn Experimental Station, Chungnam Agricultural Research and Extention) ;
  • Chang, Ki-Woon (Dep't of Agricultural Chemistry, Chungnam Nat'l University) ;
  • 발행 : 2000.12.31
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초록

구기자나무의 부위별 물추출물이 LPS (lipopolysaccharide) 및 Con A (concanavalin A)에 의한 마우스의 비장세포 증식능에 미치는 영향을 시험한 결과 부위별 면역 활성중 과실에서 의 No mil 처리구에서는 $0.1mg/ml{\sim}0.5mg/ml$ 농도에서, LPS 처리구에서는 $0.01mg/ml{\sim}0.1mg/ml$의 농도에서 B-cell (체액성 면역)의 분열증식을 촉진시켰다. 잎과 뿌리는 LPS 처리구에서 0.1mg/ml 까지 비장세포의 분열증식을 촉진시켰으며 Con A 처리구에서는 T-cell (세포성 면역)의 증식효과가 없었다.

To evaluate the biological effects of boxthorn (Lycium chinense Mill.) extracts on the immune response systems, the mitogenic effects were tested by LPS (lipopolysaccharide) and Con A (concanavalin A) using water extracts from various parts of Lycium chinense Mill. The proliferation of B-lymphocytes which were activated by the mitogen, LPS, was markedly increased in the concentration of 0.1mg/ml to 0.5mg/ml, but inhibited in more than 0.5mg/ml. It increased only proliferation of B-lymphocytes but not that of T-lymphocytes by Con A. There was no difference between boxthorn species in immune response. Water extracts of various parts in boxthorn enhanced the humoral immune response which was related to B-lymphocytes.

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