Korean Journal of Medicinal Crop Science (한국약용작물학회지)

The Korean Society of Medicinal Crop Science (한국약용작물학회)
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Effects of Extracts from Various Parts of Lycium chinense Mill. on the Proliferation of Mouse Spleen Cells

구기자 부위별 추출물이 흰쥐 비장세포의 증식에 미치는 영향

  • Park, Jong-Sang (Microplants Co., Ltd. R&D Center) ;
  • Park, Jong-Dae (Korea Ginseng & Tobacco Research Institute) ;
  • Lee, Bong-Chun (Chungyang Boxthorn Experimental Station, Chungnam Agricultural Research and Extention) ;
  • Choi, Kang-Ju (Korea Ginseng & Tobacco Research Institute) ;
  • Ra, Sang-Wook (Chungyang Boxthorn Experimental Station, Chungnam Agricultural Research and Extention) ;
  • Chang, Ki-Woon (Dep't of Agricultural Chemistry, Chungnam Nat'l University) ;
  • 박종상 ((주) 마이크로플랜츠 중앙연구소) ;
  • 박종대 (한국인삼연초연구원) ;
  • 이봉춘 (충남농업기술원 청양구기자시험장) ;
  • 최강주 (한국인삼연초연구원) ;
  • 라상욱 (충남농업기술원 청양구기자시험장) ;
  • 장기운 (충남대학교 농화학과) ;
  • Published : 2000.12.31
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Abstract

To evaluate the biological effects of boxthorn (Lycium chinense Mill.) extracts on the immune response systems, the mitogenic effects were tested by LPS (lipopolysaccharide) and Con A (concanavalin A) using water extracts from various parts of Lycium chinense Mill. The proliferation of B-lymphocytes which were activated by the mitogen, LPS, was markedly increased in the concentration of 0.1mg/ml to 0.5mg/ml, but inhibited in more than 0.5mg/ml. It increased only proliferation of B-lymphocytes but not that of T-lymphocytes by Con A. There was no difference between boxthorn species in immune response. Water extracts of various parts in boxthorn enhanced the humoral immune response which was related to B-lymphocytes.

구기자나무의 부위별 물추출물이 LPS (lipopolysaccharide) 및 Con A (concanavalin A)에 의한 마우스의 비장세포 증식능에 미치는 영향을 시험한 결과 부위별 면역 활성중 과실에서 의 No mil 처리구에서는 $0.1mg/ml{\sim}0.5mg/ml$ 농도에서, LPS 처리구에서는 $0.01mg/ml{\sim}0.1mg/ml$의 농도에서 B-cell (체액성 면역)의 분열증식을 촉진시켰다. 잎과 뿌리는 LPS 처리구에서 0.1mg/ml 까지 비장세포의 분열증식을 촉진시켰으며 Con A 처리구에서는 T-cell (세포성 면역)의 증식효과가 없었다.

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