한국식품과학회지 (Korean Journal of Food Science and Technology)
- 제32권4호
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- Pages.964-969
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- 2000
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- 0367-6293(pISSN)
E-screen assay 및 자궁비대반응시험 (Uterotrophic assay)을 이용한 di-(2-ethylhexyl) adipate의 에스트로겐성 작용에 관한 연구
Study on the Estrogenic Activity of Di-(2-Ethylhexyl) Adipate in E-Screen Assay and Uterotrophic Assay
- 한순영 (식품의약품안전청 국립독성연구소) ;
- 김형식 (식품의약품안전청 국립독성연구소) ;
- 한상국 (식품의약품안전청 국립독성연구소) ;
- 이이다 (식품의약품안전청 국립독성연구소) ;
- 양규환 (식품의약품안전청 국립독성연구소) ;
- 박귀례 (식품의약품안전청 국립독성연구소)
- Han, Soon-Young (National Institute of Toxicological Research, Korea Food and Drug Administration) ;
- Kim, Hyung-Sik (National Institute of Toxicological Research, Korea Food and Drug Administration) ;
- Han, Sang-Kook (National Institute of Toxicological Research, Korea Food and Drug Administration) ;
- Lee, Rhee-Da (National Institute of Toxicological Research, Korea Food and Drug Administration) ;
- Yang, Kyu-Whan (National Institute of Toxicological Research, Korea Food and Drug Administration) ;
- Park, Kui-Lea (National Institute of Toxicological Research, Korea Food and Drug Administration)
- 발행 : 2000.08.30
초록
랩 등 PVC 제품의 가소제인 DEHA의 에스트로겐 활성을 검색하기 위하여 내분비계 장애작용 중 에스트로겐성 작용을 검색하는 대표적인 방법인 in vitro E-screen assay와 OECD 및 미국 EPA EDSTAC에서 권고하고 있는 in vivo 난소절제 랫드를 이용한 자궁 비대반응시험(uterotrophic assay)을 실시하였다. 시험결과
Di-(2-ethylhexyl) adipate(DEHA) has been used extensively as a plasticizer in the manufacture of plastic products such as PVC films. Though, phthalate esters plasticizers have been known to induce endocrine system-mediated responses, few studies have been conducted for the screening of estrogenic activity of DEHA, an adipate plasticizer. This study was initiated to evaluate the estrogenic activity of DEHA by in vitro E-screen assay and in vivo uterotrophic assay. MCF-7 human breast cancer cells were treated with