Korean Journal of Pharmacognosy (생약학회지)
- Volume 31 Issue 4
- /
- Pages.383-389
- /
- 2000
- /
- 0253-3073(pISSN)
- /
- 2288-9299(eISSN)
Study on Hepatoprotective and Antioxidant Activities of Korean Red Ginseng-Mixed Formula
홍삼복합제의 보간 및 항산화 작용에 대한 연구
- Kang, Chang-Hee (Oriental Medical College, Taejon University) ;
-
Kim, Dong-Hee
(Oriental Medical College, Taejon University) ;
-
Ryu, Shi-Yong
(Korea Research Institute of Chemical Technology) ;
- Kim, Sung-Hoon (Department of Oncology, Graduate School of East-West Medical Science, Kyunghee University)
- Published : 2000.12.30
Abstract
GRF (Korean Red Ginseng mixed formula) consists of six herbs such as Ginseng Radix rubra Koreana, Lycii Fructus, Artemisiae Capillaris Herba, Poria, and Glycyrrhizae Radix and Hoveniae Fructus. For the evaluation of hepatoprotective effect of GRF, the study was performed on protective effect against hepatic damage induced by galactosamine in vitro and ccl4 in vivo and also elucidate antioxidant activity. In vitro assay with 1.1 mM galactosamine, protection (%) was 44% (GR), and 58% (GRF-A) at 50 ug/ml. GRF effectively protected fatty degenertion and necrosis in murine hepatic damage induced by ccl4. For the -antioxidant study, GRF inhibited hemolysis of erythrocyte and decolored DPPH (2,2-diphenyl-l-picrylhydrazyl) free radical in a dose dependent manner more effetively than GR alone in vitro. GRF and GR significantly suppressed the time course