생약학회지 (Korean Journal of Pharmacognosy)
- 제31권3호
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- Pages.351-356
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- 2000
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- 0253-3073(pISSN)
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- 2288-9299(eISSN)
Bergenin 및 Acetylbergenin의 Galactosamine 유발 간독성에 대한 치료효과
Therapeutic Effects of Bergenin and Acetylbergenin on Galactosamine-induced Hepatotoxicity in Rats
- Lim, Hwa-Kyung (College of Pharmacy, Chungbuk National University) ;
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Choi, Jong-Won
(College of Pharmacy, Kyungsung University) ;
- Kim, Hack-Seang (College of Pharmacy, Chungbuk National University)
- 발행 : 2000.09.30
초록
The hepatoprotective effects of bergenin and its derivative, acetylbergenin, were evaluated against D-galactosamine-induced liver damage in rats. Bergenin is a C-glucoside of 4-O-methyl gallic acid that has been isolated from the cortex of Mallotus japonicus (Euphorbiaceae). Acetylbergenin was synthesized from acetylation of bergenin to increase lipophilic and physiological activities. Bergenin (50, 100 and 200 mg/kg) and acetylbergenin (25, 50 and 100 mg/kg) were administered orally once daily for successive 5 days after the injection of galactosamine (400 mg/kg, i.p.), respectively. The substantially elevated serum enzyme activities of alanine/aspartate aminotransferase, sorbitol dehydrogenase and