Korean Journal of Biological Psychiatry (생물정신의학)

The Korean Society of Biological Psychiatry (대한생물정신의학회)
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Platelet Serotonin Level and Psychological Features of the Suicidal Attempters

자살시도 환자의 혈소판내 세로토닌 농도와 심리학적 특성에 관한 연구

  • Jeong, Hee Yeon (Department of Psychiatry, College of Medicine, Soonchunhyang University) ;
  • Kwon, Young Joon (Department of Psychiatry, College of Medicine, Soonchunhyang University) ;
  • Park, In Joon (Department of Psychiatry, College of Medicine, Soonchunhyang University) ;
  • Hong, Se Yong (Department of Internal Medicine, College of Medicine, Soonchunhyang University) ;
  • Choi, Eui Jung (Department of Psychiatry, College of Medicine, Soonchunhyang University) ;
  • Jin, Hyuk-Hee (Department of Psychiatry, College of Medicine, Soonchunhyang University)
  • 정희연 (순천향대학교 의과대학 천안병원 신경정신과학교실) ;
  • 권영준 (순천향대학교 의과대학 천안병원 신경정신과학교실) ;
  • 박인준 (순천향대학교 의과대학 천안병원 신경정신과학교실) ;
  • 홍세용 (순천향대학교 의과대학 천안병원 내과학교실) ;
  • 최의정 (순천향대학교 의과대학 천안병원 신경정신과학교실) ;
  • 진혁희 (순천향대학교 의과대학 구미병원 신경정신과학교실)
  • Published : 1999.06.25
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Abstract

Objectives : Significant progress has been made in understanding psychosocial, psychological, and environmental factors associated with suicide. However it is only recently that attention has been paid to the understanding of the neurobiology of suicide. The aim of this study was to examine the relationship between platelet serotonin level and suicidal behavior and psychological features of the suicidal attempters. Methods : After a suicidal attempt platelet serotonin level was measured from 21 patients and compared it with those from depression patients and normal controls. Also MMPI, HAM-D, Barratt impulsiveness scale(BIS) were done to evaluate their psychological features. Results : 1) There was no significant difference in sex ratio of the suicidal attempters. 2) There was no significant difference in platelet serotonin levels among three groups. 3) The analysis of MMPI revealed that the scores of D, Hs, Pt in clinical scales were significantly higher in suicide patients and scores of D, Pa, Si were in depression patients. 4) The HAM-D score was significantly higher in depression and suicide patients, especially in depression patients. 5) The analysis of Barratt impulsiveness scale revealed that the scores of nonplanning, motor and cognitive impulsiveness scale were significantly higher in suicide patients. Conclusions : There was no significant difference in platelet serotonin levels among three groups. However the analysis of psychological features revealed significant differences. Therefore we concluded that psychological examinations are benefit to evaluate the suicidal tendency.

자살 시도군 21명, 우울증 환자군 14명, 그리고 정상 대조군 10명을 대상으로 혈소판내 세로토닌의 농도, 반 구조화된 설문조사, 다면적 인성검사, HAM-D, 충동성 검사를 시행하여 비교한 결과는 다음과 같았으며, 자살 시도군의 자살방법은 대부분 농약 중독이었다. 1) 자살 시도자의 남녀 비는 차이가 없었다. 2) 혈소판내의 세로토닌의 농도는 자살 시도군, 우울증 환자군 및 정상 대조군간에 차이가 없었다. 3) 다면적 인성검사 결과는 자살 시도군의 경우 D, Hs, Pt 척도가 높았으며, 우울증 환자군의 경우 D, Pa, Si 척도가 높았다. 4) HAM-D 점수는 우울증 환자군과 자살 시도군 모두에서 높았으며, 특히 우울증 환자군의 경우 더 의미 있게 높았다. 5) 충동성 검사 결과는 자살 시도군이 우울증 환자군에 비하여 무계획 충동성, 운동 충동성이 의미 있게 높았다.

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