The Journal of the Korean bone and joint tumor society (대한골관절종양학회지)

The Korean Musculoskeletal Tumor Society (대한근골격종양학회)
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Expression of c-fos Protein in Fibrous Dysplasia and Osteofibrous Dysplasia

섬유성 이형성증 및 골섬유성 이형성증에서의 c-fos 단백 발현

  • Park, Hye-Rim (Department of Pathology, College of Medicine, Hallym University) ;
  • Park, Yong-Koo (Department of Pathology, College of Medicine, Kyung Hee University) ;
  • Kim, Duck-Whan (Department of Pathology, College of Medicine, Hallym University)
  • 박혜림 (한림대학교 의과대학 병리학교실) ;
  • 박용구 (경희대학교 의과대학 병리학교실) ;
  • 김덕환 (한림대학교 의과대학 병리학교실)
  • Published : 1999.12.30
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Abstract

The purpose of this study was to evaluate the role of c-fos oncogenes in the development of fibrous dysplasia and osteofibrous dysplasia. The immunohistochemical expression of c-fos protein was evaluated in 15 cases of fibrous dysplasia and 8 cases of osteofibrous dysplasia. Ten cases of fibrous dysplasia were weakly positive with c-fos. Six cases of osteofibrous dysplasia were weakly positive and the remaining two cases were strongly positive. The overall expression of c-fos protein is weaker than high-grade osteosarcoma, thus the implication of c-fos protein is little in the development of these tumors. Fibrous dysplasia and osteofibrous dysplasia share some features of characteristic histology and c-fos expression.

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