Journal of Haehwa Medicine (혜화의학회지)
- Volume 8 Issue 1
- /
- Pages.625-641
- /
- 1999
- /
- 2586-3002(pISSN)
- /
- 2586-3347(eISSN)
A Study on the Effects of Sungshimsan on the Heart Lipid Peroxide and Metabolic Enzyme System in Senescence Induced Rats
노화과정(老化過程)의 흰쥐에서 성심산(醒心散)이 심장(心臟)의 대사효소계(代謝酵素系)에 미치는 영향(影響)
- Kwak, Jung-mun (Dept. of Oriental Medicine Graduate School, Tae-jeon University) ;
- Oh, Min-Suck (Dept. of Oriental Medicine Graduate School, Tae-jeon University) ;
- Song, Tae-won (Dept. of Oriental Medicine Graduate School, Tae-jeon University)
- Published : 1999.09.01
Abstract
Aging occurs as a part of maturation as the time progresses which manifests in the human body causing morphological and functional degeneration, eventually leading to death. This experimental study was conducted to investigate a herbal formula to fortify the heart with easy clinical applications. Sungshimsan was chosen to study its effects in heart lipid peroxide and metabolic enzyme system in senescence induced rats. After pre-treatment of Sungshimsan for 2 weeks at the dosage of A (100mg/kg), B (250mg/kg), C (350mg/kg), and D (500mg/kg), a lipid peroxide and metabolic enzyme system changes of the heart were meaured in 32 weeks old rats. The following results were obtained in this study: 1. The contents of lipid peroxide was significantly reduced in the experimental groups treated with greater than 2 weeks at 250mg/kg. 2. The enzymatic activity of cytochrome P-450, cytochrome b5, and NADPH-cytochrome P450 reductase were significantly decreased in the 250mg/kg, 350mg/kg, and 500mg/kg experimental groups. 3. The activity of glutathione and glutathione S-transferase were significantly increased in the 250mg/kg, 350mg/kg, and 500mg/kg experimental groups. 4. The activity of glutathione reductase and glutathione peroxidase were not influenced compared to the control group. 5. The activity of
Keywords