Journal of Microbiology and Biotechnology

The Korean Society for Microbiology and Biotechnology (한국미생물·생명공학회)
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Antibacterial Activity of Antimycotic Miconazole against Methicillin-Resistant Staphylococcus aureus

  • LEE, SANG-HWA (Korea Research Institute of Bioscience and Biotechnology) ;
  • CHANG-JIN KIM (Korea Research Institute of Bioscience and Biotechnology)
  • Published : 1999.10.01
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Abstract

Miconazole was estimated to have a minimum inhibitory concentration of 0.78 ㎍/㎖ against the methicillin-resistant strains of Staphylococcus aureus (MRSA). The antibacterial activity of miconazole against MRSA was bacteriostatic in cation-adjusted Mueller-Hinton broth, but bacteriocidal in saline solution. The anti-MRSA activity of miconazole did not show a significant change under the susceptibility-testing conditions such as various inoculum sizes, pHs, or cations (Ca/sup ++/ or Mg/sup ++/) which was added to the medium. However, the anti-MRSA activity of miconazole was completely suppressed by lipophilic a-tocopherol (50 ㎍/㎖), but definitely not by water-soluble ascorbic acid.

Keywords

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