Journal of Microbiology and Biotechnology
- Volume 9 Issue 1
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- Pages.106-112
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- 1999
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- 1017-7825(pISSN)
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- 1738-8872(eISSN)
Newly Synthesized Phosphodiesterase 4 (PDE4) Inhibitor, DWP205505, Inhibits TNF-$\alpha$ Secretion and mRNA Expression
- Lee, Suk-Kyeong (Research Institute of Immunobiology, Catholic Research Institute of Medical Science, The Catholic University of Korea) ;
- Lee, Sun-A (Research Institute of Immunobiology, Catholic Research Institute of Medical Science, The Catholic University of Korea) ;
- Byun, Hye-Sin (Research Institute of Immunobiology, Catholic Research Institute of Medical Science, The Catholic University of Korea) ;
- Cho, Mi-La (The Center for Rheumatic Disease, Kangnam St. Mary′s Hospital, College of Medicine, Department of Internal medicine, The Catholic University of Korea) ;
- Kim, Wan-Uk (The Center for Rheumatic Disease, Kangnam St. Mary′s Hospital, College of Medicine, Department of Internal medicine, The Catholic University of Korea) ;
- Park, Sung-Hwan (The Center for Rheumatic Disease, Kangnam St. Mary′s Hospital, College of Medicine, Department of Internal medicine, The Catholic University of Korea) ;
- Cho, Chul-Soo (The Center for Rheumatic Disease, Kangnam St. Mary′s Hospital, College of Medicine, Department of Internal medicine, The Catholic University of Korea) ;
- Joo, Young-Shil (The Center for Rheumatic Disease, Kangnam St. Mary′s Hospital, College of Medicine, Department of Internal medicine, The Catholic University of Korea) ;
- Lee, Shin-Seok (The Center for Rheumatic Disease, Kangnam St. Mary′s Hospital, College of Medicine, Department of Internal medicine, The Catholic University of Korea) ;
- Yoo, Eun-Sook (Research and Development Center, Daweoong Pharmaceutical Co., Ltd.) ;
- Son, Ho-Jung (Research and Development Center, Daweoong Pharmaceutical Co., Ltd.) ;
- Kim, Ho-Youn (Research Institute of Immunobiology, Catholic Research Institute of Medical Science, The Catholic University of Korea)
- Published : 1999.02.01
Abstract
The therapeutic potential of phosphodiesterase 4(PDE4) inhibitors in inflammatory diseases including some autoimmune diseases has been explored recently with some hopeful results. These PDE4 inhibitors are thought to show their anti-inflammatory effect by down-regulating tumor necrosis factor-a (TNF-
Keywords
- Phosphodiesterase 4 inhibitor;
- TNF-$\alpha$;
- IL-l0;
- Rheumatoid arthritis;
- Peripheral blood mononuclear cells;
- Synovial fluid mononuclear cells