Effects of Ketoprofen on Wound Healing in Rats

Ketoprofen이 랫트의 창상치유에 미치는 영향

  • 구자동 (건국대학교 축산대학 수의학부 외과학교실) ;
  • 배춘식 (건국대학교 축산대학 수의학부 외과학교실) ;
  • 장경진 (건국대학교 축산대학 수의학부 외과학교실)
  • Published : 1999.06.01

Abstract

Ketoprofen has been used as nonsteroidal anti-inflammatory (NSAI) agent for analgesia in surgical patients and increasing numbers of surgical patients are chronically take some forms of NSAI drugs. The purpose of this study was to investigate the therapeutic effects of ketoprofen on the healing of a closed linear surgical wound and on the contraction of an opened surgical wound in rats. The experimental groups were divided into two groups and ten rats were allocated in each group. In ketoprofen-treated group, the rats were given 2.5 mg/mg/day of ketoprofen by s.c. for ten days. In control group, the rats were given 1ml of benzyl alcohol and distilled water by s.c. for ten days. After time period, all rats were sacrificed, and the breaking strength and the collagen concentrations, at the wound site, were measured. In ketoprofen-treated group, the mean breaking strength and the mean collagen concentration were significantly decreased when compared with those of controls. The ketoprofen-treated group had shown a mean rate of wound contraction less than that of the control, although not statistically significant. These results suggested that ketoprofen impaired wound healing.

Keywords

References

  1. Surgery v.97 The effect of metronidazole on wound healing in rats Borden,E.B.;Sammartano,R.J.;Dembe,C.;Boiey,S.J.
  2. Gen Pharmac v.24 Ketorolac tromethamine: an experimental study of its analgesic effects in the rat Bustamante,D.;Paeile,C.
  3. J Pharma Scie v.79 Anti-inflammatory activity of ketoprofen gel on carrageenan-induced paw edema in rats Chi,S.C.;Jun,H.W.
  4. Am J Sports Med v.16 Effect of a NSAID on the healing of ligaments Dahners,L.E.;Gilbert,J.A.;Lester,G.E.
  5. Arch Dermatol Res v.290 no.SUP. Animal models for wound repair Davidson,J.M.
  6. Indian J Exp Biol v.24 Effects of non steroidal anti-inflammatory agents(NSAIAs) on wound healing Diwan,P.V.;Kulkarni,D.R.
  7. Ann Surg v.177 Effects of vitamin A and glucocorticoids upon inflammation and collagen synthesis Ehrlich,H.P.;Tarver,H.;Hunt,T.K.
  8. Pharmaco Research v.33 Ketoprofen lysine salt inhibits disuse-induced osteopenia in a new non-traumatic immobilization model in the rat Fiorentino,S.;Melillo,G.;Fedele,G.
  9. Ann Plast Surg v.37 The effects of chronic ketorolac tromethamine(Toradol) on wound healing Haws,M.J.;Brown,R.E.;Suchy,H.;Roth,A.C.;Kucan,J.O.
  10. Ann Plast Surg v.32 Vitamin A-soaked gelfoam sponges and wound healing in steroid-treated animals Haws,M.J.;Brown,R.E.;Suchy,H.;Roth,A.C.
  11. Chirality v.4 Enantioselective pharmacodynamics of the nonsteroidial anti-inflammatory drug ketoprofen Hayball,P.J.;Nation,R.L.;bochner,F.
  12. J Am Acad Dermatol v.15 Vitamin A and wound healing Hunt,T.K.
  13. World J Surg v.4 Disorders of wound healing Hunt,T.K.
  14. Analytical Biochemistry v.105 Monitoring of collagen and collagen fragment in chromatography of protein mixtures Huszar,G.;Maiocco,J.;Naftolin,F.
  15. Acta Orthop Scand v.60 no.1 Indomethacin and bone remodeling Keller,J.;Bayer-Kristensen,I.
  16. Arch Int Pharmacodyn v.237 Studies on the effects of anti-inflammatory action of benzoyl-hydrotropic acid(ketoprofen) and other drugs, with special reference to prostaglandin synthesis Kubota,T.;Komatsu,H.;Kawamoto,H.;Yamada,T.
  17. Gastroenterology v.98 Rectal administration of nonsteroidal anti-inflammatory drugs Ligumsky,M.;Sestieri,M.
  18. J Surg Res v.36 Ibuprofen inhibition of post-surgical adhesion formation: A time and dose response biochemical evaluation in rabbits Nishimura,K.;Nakamura,R.M.;Dizerega,G.S.
  19. Clin Plast Surg v.25 Physiology of the chronic wound Nwomeh,B.C.;Yager,D.R.;Cohen,K.
  20. Obsterics & Gynecology v.60 The use ibuprofen and dexamethasone in the prevention of postoperative adhesion formation O'Brien,W.F.;Drake,T.S.;Bibro,M.C.
  21. J Am Acad Dermatology v.18 Compromised wound repair caused by perioperative use of ibuprofen Proper,S.A.;Fenske,N.A.;Burnett,S.M.;Luria,L.W.
  22. Indian J Med Res v.92 Comparative evaluation of tolmetin & tolmetin-zinc on wound-repair & inflammation Rao,C.M.;Ramesh,K.V.;Bairy,K.L.;Kulkarni,D.R.
  23. Clin Biochem v.29 A simplified method for the analysis of hydroxyproline in biological tissues Reddy,G.K.;Enwemka,C.S.
  24. Gastroenterology v.69 An intestinal disease produced experimentally by prostaglandin deficiency Robert,A.
  25. Prog Surg v.2 Some aspects of the repair process in mammals Russell,P.S.;Billingham,R.E.
  26. Arch Surg v.90 Acceleration of open wound healing by cartilage Sabo,J.C.;Oberlander,L.
  27. Acta Chir Scand v.147 The effect of methylprednisolone and vitamin A on wound healing Salmela,K.;Ahonen,J.
  28. Br J Surg v.72 Experimental wound healing: increased breaking strength and collagen synthetic activity in abdominal fascial wounds healing with secondary closure of the skin Scott,P.G.;Chambers,M.;Johnson,B.W.;Williams,H.T.
  29. J Surg Res v.40 Cortisone, vitamin A, and wound healing: The importance of measuring wound surface area Smith,K.P.;Zardiackas,L.D.
  30. Lancet v.1 Non-steroidal anti-inflammatory drug and bleeding peptic ulcer Somerville,K.;Faulkner,G.;Langman,M.
  31. Ann Surg v.173 Effect of delayed administration of corticosteroids on wound contraction Stephens,F.O.;Dunphy,J.E.;Hunt,T.K.
  32. Chirality v.5 Stereoselective cyclooxygenase inhibition in cellular models by the enantiomers of ketoprofen Suesa,N.;Fernandez,M.F.;Gutierrez,M.
  33. Rad Res v.143 Postoperative irradiation impairs or enhances wound strength depending on time of administration Vegesna,V.;McBride,W.H.;Withers,H.R.
  34. Experientia v.29 A comparative study of some anti-inflammatory drugs in wound healing Velasco,M.;Guaitero,E.
  35. Scand J Rheumatol v.90 no.SUP. 20 year's experience with ketoprofen Veys,E.M.
  36. Cell Immunol v.105 Regulation of human peripheral blood monocyte collagenase by prostaglandins and anti-inflammatory drugs Wahl,L.M.;Lampel,L.L.
  37. Anesthesiology v.76 Comparison ketorolac and morphine as adjuvants during pediatric surgery Watcha,M.F.
  38. 한국임상수의학회지 v.10 가토 창상치유에 대한 항균연고제의 효과 권순경