KSBB Journal

The Korean Society for Biotechnology and Bioengineering (한국생물공학회)
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Binding Characteristics of Molecularly Imprinted Polymers for Ibuprofen Enantiomers

아이뷰프로펜 이성질체에 대한 molecularly imprinted polymers의 binding 특성

  • 신명근 (강원대학교 화학공학과) ;
  • 조규헌 (강원대학교 화학공학과)
  • Published : 1999.06.01
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Abstract

The molecularly imprinted polymers(MIPs) synthesized at various polymerization conditions were examined as ibuprofen receptors in terms of binding characteristics. The 4-vinylpyridine polymers had 1.2 times higher adsorption capability for (S)-(+)-ibuprofen than the methacrylic acid polymers. The methacrylic acid polymers synthesized by UV radiation had 1.9 times higher selectivity for (S)-(+)-ibuprofen compared to those by thermal initiation. Effects of various solvents for binding were also examined in this research. According to the Scatchard analysis, the (S)-(+)-ibuprofen artificial receptors had two different kinds of binding sites for (S)-(+)-ibuprofen while having only single kind of binding site for ketoprofen. The binding sites of (S)-(+)-ibuprofen, n were calculated as 4.3~4.9 $\mu$mol/g and the dissociation constants, $K_D$ were 0.68 mM for the specific binding.

Keywords

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