Toxicological Research

  • 제15권1호
  • /
  • Pages.65-68
  • /
  • 1999
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  • 1976-8257(pISSN)
  • /
  • 2234-2753(eISSN)
한국독성학회 (Korean Society of Toxicology & Korea Environmental Mutagen Society)
권호 표지

Evaluation of Subcutaneous and Intramuscular Irritation of the Typhoid Vaccine in Rabbits

  • Ihm, Jong-Hee (Department of Veterinary public Health, College of Veterinary Medicine, Seoul National University) ;
  • Che, Jeong-Hwan (Department of Veterinary public Health, College of Veterinary Medicine, Seoul National University) ;
  • Li, Guang-Xun (Department of Veterinary public Health, College of Veterinary Medicine, Seoul National University) ;
  • Kang, Byeong-Cheol (Department of Veterinary public Health, College of Veterinary Medicine, Seoul National University)
  • 발행 : 1999.03.01
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초록

A newly developed typhoid vaccine was tested for subcutaneous and intramuscular irritationin male Ner Zealand White rabbits. In subcutaneous and intramuscular irritation tests, there were no observed clinical signs, body weight changes and gross pathologic findings at doses of 1 mg/ml and 0.0125 mg/ml during experimental period. However, in positive control (0.75% acetic acid), we could find various lesions that had hemorrhage, necrosis and infiltration of inflammation cells in both subcutaneous and muscular tissues. From these results, we suggest that typhoid vaccine is not irritant in subcutaneous and muscular tissue of rabbits.

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참고문헌

  1. BMJ v.316 no.10 Typhoid fever vaccines: a meta-analysis of studies on efficacy and toxicity Engles, E.A.;Falagas, M.E.;Lau, J.;Bennish, M.L.
  2. Arch. Intern. Med. v.144 no.3 Typhoid fever epidemic with remarkably few clinical signs and symptoms Klotz, S.A.;Jorgensen, J.H.;Buckwold, F.J.;Craven, P.C.
  3. Trends Microbiol v.6 no.4 Typhoid fever-important issues still remain Pang, T.;Levine, M.M.;Ivanoff, B.;Wain, J.;Finlay, B.B.
  4. Rev. Prat. v.40 no.25 Typhoid fever epidemiology, etiology, physiopathology, diagnosis, clinical course and prognosis, treatment Reynes, J.;Bertrand, A.
  5. Notification no.98-56 Guidelines for Toxicity Testing of Pharmaceuticals Korea Food and Drug Administration guideline