Journal of Chest Surgery

The Korean Society for Thoracic and Cardiovascular Surgery (대한심장혈관흉부외과학회)
권호 표지

Calcification-resistant Effect of Surface-modified Biologic Arteries by Sulfonated Polyethyleneoxide

술폰산화 폴리에틸렌옥사이드로 표면개질한 생체동맥의 석회화 저항 효과

  • Kim, Hyoung-Mook (Department of Thoracic and Cardiovascular Surgery, College of Medicine, Korea University) ;
  • Baek, Man-Jong (Department of Thoracic and Cardiovascular Surgery, College of Medicine, Korea University) ;
  • Sun, Kyung (Department of Thoracic and Cardiovascular Surgery, College of Medicine, Korea University) ;
  • Lee, Seung-Yeol (Department of Thoracic and Cardiovascular Surgery, College of Medicine, Korea University) ;
  • Lee, Song-Am (Department of Thoracic and Cardiovascular Surgery, College of Medicine, Korea University) ;
  • Kim, Kwang-Taik (Department of Thoracic and Cardiovascular Surgery, College of Medicine, Korea University) ;
  • Lee, In-Sung (Department of Thoracic and Cardiovascular Surgery, College of Medicine, Korea University) ;
  • Lee, Won-Kyu (Polymer Chemistry Laboratory, Korea Institute of Science and Technology) ;
  • Park, Ki-Dong (Polymer Chemistry Laboratory, Korea Institute of Science and Technology) ;
  • Kim, Young-Ha (Polymer Chemistry Laboratory, Korea Institute of Science and Technology)
  • 김형묵 (고려대학교 의과대학 흉부외과학 교실) ;
  • 백만종 (고려대학교 의과대학 흉부외과학 교실) ;
  • 선경 (고려대학교 의과대학 흉부외과학 교실) ;
  • 이승렬 (고려대학교 의과대학 흉부외과학 교실) ;
  • 이송암 (고려대학교 의과대학 흉부외과학 교실) ;
  • 김광택 (고려대학교 의과대학 흉부외과학 교실) ;
  • 이인성 (고려대학교 의과대학 흉부외과학 교실) ;
  • 이원규 (한국 과학기술원 고분자화학연구소) ;
  • 박기동 (한국 과학기술원 고분자화학연구소) ;
  • 김영하 (한국 과학기술원 고분자화학연구소)
  • Published : 1999.11.01
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Abstract

Background: Calcific degeneration is the major cause of clinical failure of glutaraldehyde (GA) crosslinked bioprosthetic tissues implanted in the body and necessitates the reoperation or causes death. Surface modification of biologic tissues using sulfonated polyethyleneoixde (PEO-SO3) has been suggested to significantly enhance blood compatibility, biostability and calcification-resistance by means of the synergistic effect of highly mobile and hydrophilic PEO chains and electrical repulsion of negatively charged sulfonate groups. This study was designed to evaluate the anticalcification effect of surface-modification of biologic arteries by direct coupling of PEO-SO3 after GA fixation and changes of calcification according to the implantation period through the quantitative investigation of the deposited calcium and phosphorous contents of the biologic arterial tissues in the canine circulatory implantation model. Material and Method: Total of 16 fresh canine carotid arteries were harvested from eight adult dogs and divided in to GA group(n =8) and PEO-SO3 group(n=8). Sulfonation of diamino-terminated PEO was performed using propane sultone. Canine carotid arteries were only crosslinked with 0.65% GA solution in GA group and modified by direct coupling 5% PEO-SO3 solution after GA crosslinkage for 2 days and stabilized by NaBH4 solution for 16 hours in PEO-SO3 group. In both groups the resected segment of bilateral carotid arteries were reconstructed. Reconstructed segments of the two groups were analysed the quantities of calcium and phosphorous contents after 3(n=4) and 6(n=4) weeks in vivo. Result: After implantation of 3 seeks, PEO-SO3 group showed significantly less depositions.

Keywords

References

  1. CRC Crit Rev Biocompat v.2 Bioprostheric heart valve calcification: Chnical features, pathology, and prospects for prevention Levy RJ;Schoen FJ;Golomb G
  2. J Biomed Mater Res v.22 Biomaterial-associated calcification. Pathology, mechanisms, and strategies for prevention Schoen FJ;Harasaki H;Kim KM(et al.)
  3. J Biomed Mater Res v.18 Toxic reactions evoked by glutaraldehyde-fixed pericardium and cardiac valve tissue bioprosthesis Gendler E;Gendler S;Nimni ME
  4. Am J Pathol v.113 Biologic determinants of dystrophic calcification and osteocalcin deposition in glutaraldehyde-preserved porcine aortic valve leaflets implanted subcutaneously in rats Levy RJ;Shoen FJ;Levy JT;Nelson AC;Howard SL;Oshry LJ
  5. J Thorac Cardiovasc Surg v.89 In vivo hemodynamic comparison of porcine and pericardial valves Cosgrove DM;Lytle BW;Gill CC(et al.)
  6. Ann Thorac Surg v.46 Inhibition of bioprosthetic heart valve calcification with aminodiphosphonate covalently bound to residual aldehyde groups Webb CL;Benediet JJ;Schoen FJ;Linden JA;Levy RJ
  7. Biomaterials v.14 Trivalent metal ions in the prevention of calcification in glutaraldehyde treated biological tissues. Is there a chemical correlation? Tan WM;Loke WK;Tan BL;Wee A;Khor E;Goh KS
  8. J Biomed Mater Res v.27 Inhibition of calcification of glutaraldehyde pretreated porcine aortic valve cusps with sodium dodecyl sulfate. Preincubation and controlled release studies Hirsch D;Drader J;Thomas TJ;Schoen FJ;Levy JT;Levy RJ
  9. Ann Thorac Surg v.64 Refinement of the alpha aminooleic acid bioprosthetic valve anticalcification technique Gott JP;Girardot MN;Girardoi JMD(et al.)
  10. Med Instrum v.7 Interfacial phenomena and biomaterials Andrade JD
  11. J Biomed Mater Res v.23 Properties and biological interaction of polyurethane aniomers: Effect of sulfonate incorporation Grasel TG;Cooper SL
  12. J Biomed Mater Res v.25 Negative cilia concept for thromboresistance Synergistic effect of PEO and sulfonated groups grafted onto polyurethanes Han DK;Jeong SY;Kim YH;Min, BG;Cho HI
  13. J Biomed Mater Res v.27 In vivo biostability and calcification-resistance of surface-modified PU-PEO-$SO_3$ Han DK;Park KD;Jeong SY(et al.)
  14. ASAIO J v.40 Chemical modification of implantable biologic tissue for anti-calcification Park KD;Yun JY;Han DK(et al.)
  15. Biomaterials v.18 Novel anti-calcification treatment of biological tissues by grafting of sulfonated poly(ethylene oxide.) Park KD;Lee WK;Yun JY(et al.)
  16. 대흉외지 v.31 PEO-$SO_3$를 이용한 항성회화 조직첨포의 개발(I)-잡견을 이용한 대동맥과 폐동맥 이식 실험 연구 김형묵;백만종;선경 (등)
  17. 대흉외지 v.31 PEO-$SO_3$를 이용한 항석회화 조직첨포의 개발(III)-동맥과 복막 이식 실험연구- 김형묵;백만종;김광택 (등)
  18. Biomaterials v.17 Glutaraldehyde as a fixative in bioprostheses and drug delivery matrices Jayakrishnan A;Jameela SR
  19. J Card Surg v.4 Anticalcification treatments of bioprosthetic heart valves: in vivo studies in sheep Jones M;Eidbo EE;Hilbert SL;Ferrans VJ;Clark RE
  20. J Biomed Mater Res v.22 Heparin immobilization onto segmented polyurethaneurea surfaces-Effect of hydrophilic spacers Park KD;Okano T;Nojiri C;Kim SW
  21. J Biomed Mater Res v.23 Protein-resistant surfaces prepared by PEO containing block copolymer surfactants Lee JH;Kopecek J;Andrade JD
  22. Biomaterials v.16 Heparin-like anticoagulant activity of sulphonated poly(ethylene oxide) and sulphonated poly(ethylene oxide) grafted polyurethane Han DK;Lee NY;Park KD;Kim YH;Cho HI;Min BG