YAKHAK HOEJI (약학회지)

The Pharmaceutical Society of Korea (대한약학회)
권호 표지

Synthesis and Antimicrobial Activity of Glycyl Norfloxacin Derivatives

Glycyl Norfloxacin 유도체의 합성과 항균작용

  • 이현수 (중앙대학교 약학대학 의약품화학 교실) ;
  • 임채욱 (중앙대학교 약학대학 의약품화학 교실) ;
  • 임철부 (중앙대학교 약학대학 의약품화학 교실)
  • Published : 1999.08.01
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Abstract

The synthesis and antimicrobial activity of N-substituted glycyl derivatives of Norfloxacin were described. Norfloxacin was treated with chloroacetyl chloride to yield chloroacetyl norfloxacin (1). This compounds was treated with alkylamines to obtain quinolone carboxylic acids (2-6), which were reacted with pivaloyloxymethyl chloride to get pivaloyloxymethyl quinolone carboxylates (7-11). Free carboxylic quinolones (2-6) showed little stronger activities to their pivaloyloxymethyl esters (7-11). In quinolone analogues, longer alkyl chain compounds showed stronger activities than shorter one.

Keywords

References

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