Archives of Pharmacal Research
- Volume 22 Issue 4
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- Pages.372-379
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- 1999
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- 0253-6269(pISSN)
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- 1976-3786(eISSN)
Synthesis and Biological Activity of Annulated Pyrazoles as Selective COX-2 Inhibitors. I.
- Kim, Hyun-Hee (College of Pharmacy, Yeungnam University) ;
- Park, Jae-Gyu (College of Pharmacy, Yeungnam University) ;
- Moon, Tae-Chul (College of Pharmacy, Yeungnam University) ;
- Chang, Hyun-Wook (College of Pharmacy, Yeungnam University) ;
- Jahng, Yurng-Dong (College of Pharmacy, Yeungnam University)
- Published : 1999.08.01
Abstract
A series of disubstituted 4,5-polymethylenepyrazoles were synthesized and evaluated their inhibitory activities against COX-2. Some compounds showed strong (0.3 nM) inhibitory activity on COX-2 and were found somewhat selective (up to 16) on COX-2 over COX-1.