Archives of Pharmacal Research
- 제22권4호
- /
- Pages.335-339
- /
- 1999
- /
- 0253-6269(pISSN)
- /
- 1976-3786(eISSN)
Relationship Between Tyrosinase Inhibitory Action and Oxidation-Reduction Potential of Cosmetic Whitening Ingredients and Phenol Derivatives
- Sakuma, Katsuya (Faculty of Pharmaceutical Sciences, Josai University, Japan) ;
- Ogawa, Masayuki (Faculty of Pharmaceutical Sciences, Josai University, Japan) ;
- Sugibayashi, Kenji (Faculty of Pharmaceutical Sciences, Josai University, Japan) ;
- Yamada, Koh-ichi (Faculty of Pharmaceutical Sciences, Josai University, Japan) ;
- Yamamoto, Katsumi (Faculty of Pharmaceutical Sciences, Josai University, Japan)
- 발행 : 1999.08.01
초록
The oxidation-reduction potentials of cosmetic raw materials, showing tyrosinase inhibitory action, and phenolic compounds structurally similar to L-tyrosine were determined by cylcic voltammetry. The voltammograms obtained could be classified ito 4 patterns (patterns 1-4). Patterns 1, characterized by oxidation and reduction peaks as a pair, was observed with catechol, hydroquinone or phenol, and pattern 2 exhibiting another oxidation peak in addition to oxidation and reduction peaks as a pair was found with arbutin, kojic acid, resorcinol, methyl p-hydroxybenzoate and L-tyrosine as the substrate of tyrosinase. Pattern 3 with an independent oxidation peak only was expressed by L-ascorbic acid, and pattern 4 with a reduction peak only at high potentials, by hinokitiol. The tyrosinase inhibitory activity of these compounds was also evaluated using the 50% inhibitory concentration (
키워드