Antimicrobial Effect of the Extract of Sophora flavescens Ait (I)

고삼추출물의 항균효과 (I)

  • Cho, Hoon (Kuhnil Pharmaceutical Co. LTD.) ;
  • Weon, Sung-Ran (Kuhnil Pharmaceutical Co. LTD.) ;
  • Yang, Eun-Yeong (Kuhnil Pharmaceutical Co. LTD.) ;
  • Kim, Jong-Soo (Department of Chemical Engineering, Iksan College) ;
  • You, Il-Soo (Department of Chemical Engineering, Iksan College) ;
  • Ru, Do-Gon (Department of Physiology, School of Oriental Medicine, Wonkang University) ;
  • Lee, Jeong-Ho (Department of Preventive Medicine, School of Medicine, Wonkang University) ;
  • Kang, Kil-Ung (Division of Chemistry Technology & Biological Science, College of Natural Sciences, Wonkwang University) ;
  • Baek, Seung-Hwa (Division of Chemistry Technology & Biological Science, College of Natural Sciences, Wonkwang University)
  • 조훈 (건일제약(주)) ;
  • 원성란 (건일제약(주)) ;
  • 양은영 (건일제약(주)) ;
  • 김종수 (익산대학 화학공업과) ;
  • 유일수 (익산대학 화학공업과) ;
  • 류도곤 (원광대학교 한의과대학 생리학교실) ;
  • 이정호 (원광대학교 의과대학 예방의학교실) ;
  • 강길웅 (원광대학교 자연과학대학 화학기술.생명과학부) ;
  • 백승화 (원광대학교 자연과학대학 화학기술.생명과학부)
  • Published : 1999.08.01

Abstract

In order to develop a antimicrobial agent, dried Sophora flavescens Ait. was extracted with several solvents, and than antimicrobial activity was investigated. The minimal inhibitory concentration (MIC) of the extracted substance against microorganisms were also examined. Antimicrobial activity of the initial methanol extract from the sample was the strongest compared to those of other solvent extracts such as $H_2O$, n-hexane, chloroform, ethyl acetate and methanol. The methanol extract had strong growth inhibition activity against gram-postive bacteria (MIC, $25~50{\;}{\mu\textrm{g}}/ml$) such as B. subtilis. Among gram-positive bacteria tested, B. subtilis was the most susceptible to the extracted substance. The antimicrobial activity of the methanol extract from the sample had strong growth inhibition activity against gram-negative bacteria such as P. aeruginosa (MIC, $25{\;}{\mu\textrm{g}}$/ml).

Keywords

References

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