YAKHAK HOEJI (약학회지)

The Pharmaceutical Society of Korea (대한약학회)
권호 표지

Protective Effects of Extracts of Mori Cortex Radicis on Carbon Tetrachloride-induced Hepatotoxicity

사염화탄소에 의해 유발된 간독성에 대한 상백피 추출물의 간보호효과

  • 김선여 (농업과학기술원 잠사곤충부) ;
  • 이희삼 (농업과학기술원 잠사곤충부) ;
  • 류강선 (농업과학기술원 잠사곤충부) ;
  • 이은주 (서울대학교 약학대학) ;
  • 김영중 (서울대학교 약학대학)
  • Published : 1999.06.01
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Abstract

In order to evaluate the protective effects of extracts of Mori cortex radicis on carbon tetrachloride-induced hepatotoxicity, glutamic oxaloacetic transaminase, glutamic pyruvic transaminase, lactic dehydrogenase, malondiadehyde values and glutathione S-transferase activity were measured in ICR mice. The activities of serum aminotransferase and the hepatic content of lipid peroxide after carbon tetrachloride-treatment were markedly increased than normal control but those levels were significantly decreased by the treatment of butanol fraction of Mori cortex radicis mathanol extract. Glutathione S-transferase activity was decreased by carbon tetrachloride than control, but that also inhibited by the treatment of butanol fraction of Mori cortex radicis methanol extract. These results demonstrate a possible hepatoprotective role of extract role of extract of Mori cortex radicis against ${CCl_4}-induced$ hepatoxicity in vivo.

Keywords

References

  1. 생약학 한대석(외)
  2. 본초학 한국 생약학 교수협의회
  3. Plant med. v.51 Isolation and hypoglycemic activity of moran A, a glycoprotein of Morus alba root barks Hikino,H.;Mizuno,T.;Oshima,Y.;Konno,C.
  4. Chem. Pharm. Bull. v.28 a new flavone derivatives from the root barks of the cultivated mulberry tree (Morus alba L.) Nomura,T.;Fukai,T.
  5. Chem. Phar. Bull. v.33 Constituents of the cultivated mulberry tree. XXV. Structures of two natural hypotensive Diels-Alder type adducts, mulberrofurans F and G from the cultivated mulberry tree (Morus Lhou Koidz) Fukai,T.;Hanno,Y.;Hirakura,K.;Nomura,T.;Uzawa,J.
  6. フレグランスジヤ-ナル v.6 生藥의 機能과 美白效果 池田孝夫;提龍彦
  7. Biochem. Pharm. v.40 Structure-activity relationships of polymethoxy-flavones and other flavonoids as inhibitors of non-enzymic lipid peroxidation Mora,A.;Paya,M.;Rios,J.L.;Alcaraz,M.J.
  8. Am. J. Clinic. Pathol. v.28 A colorimetric method for the determination of serum glutamc oxaloacetic and glutamic pyrivic transaminase Reitman,S.;Frankel,S.
  9. Lipids v.15 Lipid peroxidation Logani,M.K.;Davis,R.E.
  10. J. Biol. Chem. v.249 Glutathione S-transferases Habig,W.H.;Pabst,M.J.;Jakoby,W.B.
  11. J. Biol. Chem. v.193 Protein measurement with the folin phenol reagent Lowry,O.H.;Rosebrough,N.J.;Farr,A.L.:Randall,R.J.
  12. Laboratory technique in biochemistry and molecular biology Berry,M.N.;Edward,A.M.;Barritt,G.J.;Burdon(ed.)
  13. Planta med. v.49 Assay method for antihepatotoxic activity using carbon tetrachloride induced cytotoxicity in primary cultured hepatocytes Kiso,Y.;Tohkin,M.;Hikino,H.
  14. Pharmacol. Rev. v.19 Carbon tetrachloride hepatotoxicity Recknigel,R.O.
  15. Bichem. Pharmacol. v.21 Effect of 3-methylchloroanthrene induction on the CCl₄-induced changes in rat hepatic microsomal enzyme system Maynard,E.H.;Bitterns,S.;James,R.G.
  16. Bichem. Pharmacol. v.35 The crucial role of oxygen partial pressures in haloalkane free radical mediated lipid peroxidation Groot,H.;Noll.T.
  17. Ann. Rev. Pharmacol. Toxicol. v.25 The regulation as hepatic glutathione Naei,K.;Tak,Y.A.;Murad,O.