Journal of Oriental Neuropsychiatry (동의신경정신과학회지)

The Korean Society of Oriental Neuropsychiatry (대한한방신경정신과학회)
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The Antioxidant Effects of Ojajiwhangeumja on the Serum & Brain Tissues of Rats -including the Effects of Ojajiwhangeumja on the Variation of the Blood of Rat-

오자지황음자(五子地黃飮子)가 노화백서(老化白鼠)의 혈액(血液) 변화(變化)와 혈청(血淸).뇌조직(腦組織)의 항산화활성(抗酸化活性)에 미치는 영향(影響)

  • Suh Kyung-Suk (Dept. of Oriental Neuropsychiatry, College of Oriental Medicine, Tae Jon University) ;
  • Lee Sang-Ryong (Dept. of Oriental Neuropsychiatry, College of Oriental Medicine, Tae Jon University)
  • 서경석 (대전대학교 한의과대학 신경정신과 교실) ;
  • 이상룡 (대전대학교 한의과대학 신경정신과 교실)
  • Published : 1999.08.30
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Abstract

This experiment was done to investigate the effects of Ojajiwhangeumja(OJWEJ) to the symptoms of senility. To prove the effects of OJWEJ we injected scopolamine(1mg/kg) to the vein of rats. And we measured the blood cells(WBC, RBC, Platelet), constituents of serum(BUN, creatinin, glucose, uric acid), endurance of films of the red blood cell to erythrocyte hemolises, the activity of cholinesterase in serum, TBA and the activity of catalase, SOD in the purified microsome of brain tissue of rats. The results were as follows; 1. The number of white blood cells, platelet was increased significantly in the group treated by OJWEJ in comparison with control group. 2. The number of BUN, creatinin, glucose of serum decreased significantly in the OJWEJ treated group compared with control group. 3. The erythrocyte hemolises in red blood cells restrained significantly in the group treated by OJWEJ in comparison with control group. 4. The activity of cholinesterase in OJWEJ treated group increased significantly compared with control group. 5. The amounts of malondialdehyde of serum decreased significantly in the OJWEJ treated group in comparison with control group. 6. The catalase in the microsome of rat brain was activated significantly in the group treated by OJWEJ compared with control group. 7. The superoxide dismutase in the group treated by OJWEJ activated significantly in comparison with control group. According to this experiment it is suggested that OJWEJ accelerates the activity of colinesterase and restrains the creation of erythrocyte hemolises and accumulation of senile substance. But I look forward to see the further research to be made.

Keywords

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