Journal of Oriental Neuropsychiatry (동의신경정신과학회지)

The Korean Society of Oriental Neuropsychiatry (대한한방신경정신과학회)
권호 표지

Effects of Chilbokyeumgamibang(七福飮加味方) on the Cerebral Cortex Neuron injured by Glucose Oxidase

칠복음가미방(七福飮加味方)이 Glucose Oxidase에 의해 손상(損傷)된 대뇌피질(大腦皮質) 신경세포(神經細胞)에 미치는 영향(影響)

  • Choi Kong-Han (Dept. of Oriental Neuropsychiatry, College of Oriental Medicine, Won Kwang University) ;
  • Gang Hyeong-Won (Dept. of Oriental Neuropsychiatry, College of Oriental Medicine, Won Kwang University) ;
  • Lyu Yeoung-Su (Dept. of Oriental Neuropsychiatry, College of Oriental Medicine, Won Kwang University)
  • 최공한 (원광대학교 한의과대학 신경정신과 교실) ;
  • 강형원 (원광대학교 한의과대학 신경정신과 교실) ;
  • 류영수 (원광대학교 한의과대학 신경정신과 교실)
  • Published : 1999.08.30
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Abstract

As the average life span have been lengthened and the rate of senile population have been raised, chronic degenerative diseases incident to aging has been increased rapidly and become a social problem. With this social background, recently, the facts that oxygen radicals(OR) have toxic effects on Central Nervous System and Peripheral Nervous System and cause neuropathy such as Parkinson's Disease, Alzheimer Disease have been turned out, and accordingly lots of studies on the mechanism of the toxic effects of OR on nerves, the diseases caused by OR and the approaches to curing the diseases have been made. The purpose of this study is to examine the toxic effects caused by Glucose Oxidase(GO) and the effects of herbal extracts such as Chilbokyeum(CBY), Chilbokyeumga Acori Rhizoma(CAR), Acori Rhizoma(AR) on the treatment of the toxic effects. For this purpose, experiments with the cultured cell from the cerebrums of new born mice were done. The results of these experiments were as follows. 1. GO, a oxygen radical, decreased the survival rate of the cultured cells on NR assay, MTT assay and amount of neurofilaments and increased the amount of total protein, lipid peroxidation and the amount of LDH. 2. CBY have efficacy of increasing the amount of neurofilaments and total protein and decreasing lipid peroxidation and the amount of LDH. 3. CAR have efficacy of increasing the amount of neurofilaments and total protein and decreasing lipid peroxidation and the amount of LDH. 4. AR have efficacy of increasing the amount of neurofilaments and total protein. From the above results, It is concluded that Chilbokyeumgamibang has marked efficacy as a treatment for the damages caused in the GO-mediated oxidative process. And Chilbokyeumgamibang is thought to have certain pharmacological effects on controlling over aging and treating Dementia. Further clinical study of this pharmacological effects of Chilbokyeumgamibang should be complemented.

Keywords

References

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